Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Neurological involvement in HIV is often associated with cognitive impairment. Although
severe and progressive neurocognitive impairment has become rare in HIV clinics in the era …

The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained
virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is …

Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to
regimens that are both expensive and associated with toxic effects. A curative intervention …

Latent HIV reservoirs are the primary hurdle to eradication of infection. Identification of
agents, pathways and molecular mechanisms that activate latent provirus may, in the …

The development of latency reversing agents that potently reactivate HIV without inducing
global T cell activation would benefit the field of HIV reservoir research and could pave the …

Targeted HIV cure strategies require definition of the mechanisms that maintain the virus.
Here, we tracked HIV replication and the persistence of infected CD4 T cells in individuals …

Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …

Latent HIV persists in CD4+ T cells in infected patients under antiretroviral therapy (ART).
Latency is associated with transcriptional silencing of the integrated provirus and driven, at …

Objective: We aimed to compare the potential for inducing HIV production and the effect on T-
cell activation of potent HDAC inhibitors undergoing clinical investigation. Design: In vitro …