The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Interactions between cancer cells and their surroundings can trigger essential signaling
cues that determine cell fate and influence the evolution of the malignant phenotype. As the …

Background Pancreatic cancer is characterized by extensive metastasis. Epithelial-
mesenchymal transition (EMT) plasticity plays a critical role in tumor progression and …

As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated
angiogenesis is a promising tactic in limiting cancer progression. The tumor …

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …