Neurotrophic factors (NTFs) are involved in the pathophysiology of neurological disorders
such as dementia, stroke and traumatic brain injury (TBI), and constitute molecular targets of …

The recent crystallographic structure of the insulin receptor (IR) extracellular domain has
brought us closer to ending several decades of speculation regarding the stoichiometry and …

Abstract Rationale: Autophagy in Schwann cells (SCs) is crucial for myelin debris
degradation and clearance following peripheral nerve injury (PNI). Nerve growth factor …

Aging is the single most important risk factor for AD (Alzheimer's disease). However, the
molecular events that connect normal aging to AD are mostly unknown. The abnormal …

Aging of the brain is characterized by marked changes in the expression levels of the
neurotrophin receptors, TrkA and p75NTR. An expression pattern in which TrkA …

Rabies virus glycoprotein (RVG) is known to be the only factor that mediates rabies infection.
The neurotrophin receptor (p75NTR), through its cysteine-rich domain 1, is a specific …

The last decade has revealed that the lifespan of an organism can be modulated by the
signaling pathway that acts downstream of the insulin/insulin-like growth factor 1 receptors …

No matter what treatment is used after nerve transection, a complete cure is impossible, so
basic and clinical research is underway to find a cure. As part of this research, autophagy is …

The prostate is one of the most abundant sources of nerve growth factor (NGF) in different
species, including humans. NGF and its receptors are implicated in the control of prostate …

NGF is a growth factor for which the role in the promotion of angiogenesis is still not
completely understood. We found that NGF promotes the pathological neovascularization …