Sphingolipids and their metabolism in physiology and disease
Studies of bioactive lipids in general and sphingolipids in particular have intensified over the
past several years, revealing an unprecedented and unanticipated complexity of the …
past several years, revealing an unprecedented and unanticipated complexity of the …
[HTML][HTML] Emerging roles of lysophospholipids in health and disease
ST Tan, T Ramesh, XR Toh, LN Nguyen - Progress in Lipid Research, 2020 - Elsevier
Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …
Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors
P Chongsathidkiet, C Jackson, S Koyama, F Loebel… - Nature medicine, 2018 - nature.com
T cell dysfunction contributes to tumor immune escape in patients with cancer and is
particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is …
particularly severe amidst glioblastoma (GBM). Among other defects, T cell lymphopenia is …
Sphingosine-1-phosphate (S1P) and S1P signaling pathway modulators, from current insights to future perspectives
GÁ Bravo, RR Cedeño, MP Casadevall… - Cells, 2022 - mdpi.com
Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are bioactive lipid molecules
that are ubiquitously expressed in the human body and play an important role in the immune …
that are ubiquitously expressed in the human body and play an important role in the immune …
Sphingosine 1-phosphate and inflammation
H Obinata, T Hla - International immunology, 2019 - academic.oup.com
Abstract AbstractSphingosine 1-phosphate (S1P), a sphingolipid mediator, regulates various
cellular functions via high-affinity G protein-coupled receptors, S1P1-5. The S1P-S1P …
cellular functions via high-affinity G protein-coupled receptors, S1P1-5. The S1P-S1P …
Inflammation, vitamin B6 and related pathways
PM Ueland, A McCann, Ø Midttun, A Ulvik - Molecular aspects of medicine, 2017 - Elsevier
The active form of vitamin B6, pyridoxal 5′-phosphate (PLP), serves as a co-factor in more
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
High-density lipoproteins: nature's multifunctional nanoparticles
High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …
Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets
TM Vu, AN Ishizu, JC Foo, XR Toh, F Zhang, DM Whee… - Nature, 2017 - nature.com
Abstract Sphingosine-1-phosphate (S1P), a potent signalling lipid secreted by red blood
cells and platelets,, plays numerous biologically significant roles,,,. However, the identity of …
cells and platelets,, plays numerous biologically significant roles,,,. However, the identity of …
Sphingosine‐1‐phosphate signaling in immune cells and inflammation: roles and therapeutic potential
M Aoki, H Aoki, R Ramanathan, NC Hait… - Mediators of …, 2016 - Wiley Online Library
Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cell processes. It is produced by the phosphorylation of sphingosine by sphingosine …
critical cell processes. It is produced by the phosphorylation of sphingosine by sphingosine …