[HTML][HTML] Pluripotent stem cell-based cell therapy—promise and challenges

S Yamanaka - Cell stem cell, 2020 - cell.com
Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent
stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable …

Human organoids: model systems for human biology and medicine

J Kim, BK Koo, JA Knoblich - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Exploration of cell state heterogeneity using single-cell proteomics through sensitivity-tailored data-independent acquisition

V Petrosius, P Aragon-Fernandez, N Üresin… - Nature …, 2023 - nature.com
Single-cell resolution analysis of complex biological tissues is fundamental to capture cell-
state heterogeneity and distinct cellular signaling patterns that remain obscured with …

ERK signalling: a master regulator of cell behaviour, life and fate

H Lavoie, J Gagnon, M Therrien - Nature reviews Molecular cell biology, 2020 - nature.com
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

Scientific, sustainability and regulatory challenges of cultured meat

MJ Post, S Levenberg, DL Kaplan, N Genovese, J Fu… - Nature Food, 2020 - nature.com
Cellular agriculture is an emerging branch of biotechnology that aims to address issues
associated with the environmental impact, animal welfare and sustainability challenges of …

Advances in pluripotent stem cells: history, mechanisms, technologies, and applications

G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

A single-cell molecular map of mouse gastrulation and early organogenesis

B Pijuan-Sala, JA Griffiths, C Guibentif, TW Hiscock… - Nature, 2019 - nature.com
Across the animal kingdom, gastrulation represents a key developmental event during which
embryonic pluripotent cells diversify into lineage-specific precursors that will generate the …

Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming

G Schiebinger, J Shu, M Tabaka, B Cleary… - Cell, 2019 - cell.com
Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying …

Cell therapy: types, regulation, and clinical benefits

AEH El-Kadiry, M Rafei, R Shammaa - Frontiers in Medicine, 2021 - frontiersin.org
Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …

Mammalian in vitro gametogenesis

M Saitou, K Hayashi - Science, 2021 - science.org
BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …