Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells
J Hasselmann, M Blurton‐Jones - Glia, 2020 - Wiley Online Library
Recent advances in the generation of microglia from human induced pluripotent stem cells
(iPSCs) have provided exciting new approaches to examine and decipher the biology of …
(iPSCs) have provided exciting new approaches to examine and decipher the biology of …
Brain organoids and the study of neurodevelopment
CA Trujillo, AR Muotri - Trends in molecular medicine, 2018 - cell.com
Brain organoids are 3D self-assembled structures composed of hundreds of thousands to
millions of cells that resemble the cellular organization and transcriptional and epigenetic …
millions of cells that resemble the cellular organization and transcriptional and epigenetic …
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions
Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …
[HTML][HTML] Zika virus targets glioblastoma stem cells through a SOX2-integrin αvβ5 axis
Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other
brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem …
brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem …
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative
agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by …
agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by …
Consequences of viral infection and cytokine production during pregnancy on brain development in offspring
D Elgueta, P Murgas, E Riquelme, G Yang… - Frontiers in …, 2022 - frontiersin.org
Infections during pregnancy can seriously damage fetal neurodevelopment by aberrantly
activating the maternal immune system, directly impacting fetal neural cells. Increasing …
activating the maternal immune system, directly impacting fetal neural cells. Increasing …
Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections
Maternal Zika virus (ZIKV) infection during pregnancy is recognized as the cause of an
epidemic of microcephaly and other neurological anomalies in human fetuses. It remains …
epidemic of microcephaly and other neurological anomalies in human fetuses. It remains …
Genome-wide CRISPR screen for Zika virus resistance in human neural cells
Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental
impact on the developing human fetal brain. To date, little is known about the factors …
impact on the developing human fetal brain. To date, little is known about the factors …
Sofosbuvir protects human brain organoids against SARS-CoV-2
COVID-19 was rapidly declared a pandemic by the World Health Organization, only three
months after the initial outbreak in Wuhan, China. Early clinical care mainly focused on …
months after the initial outbreak in Wuhan, China. Early clinical care mainly focused on …
Pathophysiology and mechanisms of Zika virus infection in the nervous system
In 2015, public awareness of Zika virus (ZIKV) rose in response to alarming statistics of
infants with microcephaly being born to women who were infected with the virus during …
infants with microcephaly being born to women who were infected with the virus during …