Molecular basis of familial and sporadic Alzheimer's disease
J Dorszewska, M Prendecki… - Current Alzheimer …, 2016 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …
(30%) causes. Among the genetic factors are genes associated with a family history of the …
MicroRNAs as potential signatures of environmental exposure or effect: a systematic review
Background: The exposome encompasses all life-course environmental exposures from the
prenatal period onward that influence health. MicroRNAs (miRNAs) are interesting entities …
prenatal period onward that influence health. MicroRNAs (miRNAs) are interesting entities …
MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification
To fully utilize the advances in omics technologies and achieve a more comprehensive
understanding of human diseases, novel computational methods are required for integrative …
understanding of human diseases, novel computational methods are required for integrative …
TransmiR v2. 0: an updated transcription factor-microRNA regulation database
Z Tong, Q Cui, J Wang, Y Zhou - Nucleic acids research, 2019 - academic.oup.com
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and
play vital roles in various biological processes. It has been reported that aberrant regulation …
play vital roles in various biological processes. It has been reported that aberrant regulation …
[HTML][HTML] Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine …
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, there are …
accumulation of amyloid plaques and neurofibrillary tangles in the brain. However, there are …
Microglia change from a reactive to an age-like phenotype with the time in culture
C Caldeira, AF Oliveira, C Cunha, AR Vaz… - Frontiers in cellular …, 2014 - frontiersin.org
Age-related neurodegenerative diseases have been associated with chronic
neuroinflammation and microglia activation. However, cumulative evidence supports that …
neuroinflammation and microglia activation. However, cumulative evidence supports that …
Analysis of microRNA and gene expression profiles in Alzheimer's disease: a meta-analysis approach
S Moradifard, M Hoseinbeyki, SM Ganji, Z Minuchehr - Scientific reports, 2018 - nature.com
Understanding the molecular mechanisms underlying Alzheimer's disease (AD) is
necessary for the diagnosis and treatment of this neurodegenerative disorder. It is therefore …
necessary for the diagnosis and treatment of this neurodegenerative disorder. It is therefore …
[HTML][HTML] Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease
Previous studies have evaluated gene expression in Alzheimer's disease (AD) brains to
identify mechanistic processes, but have been limited by the size of the datasets studied …
identify mechanistic processes, but have been limited by the size of the datasets studied …
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease
MicroRNA-146a is upregulated in the brains of patients with Alzheimer's disease (AD). Here,
we show that the rho-associated, coiled-coil containing protein kinase 1 (ROCK1) is a target …
we show that the rho-associated, coiled-coil containing protein kinase 1 (ROCK1) is a target …
Systematic characterization of circular RNA-associated CeRNA network identified novel circRNA biomarkers in Alzheimer's disease
Alzheimer's disease (AD), a degenerative disease of the central nervous system, is the most
common form of dementia in old age. The complexity and behavior of circular RNA …
common form of dementia in old age. The complexity and behavior of circular RNA …