Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

Hydroxyl radical protein footprinting (HRPF) coupled to mass spectrometry has been
successfully used to investigate a plethora of protein-related questions. The method, which …

In 1876, Fenton described a colored product obtained on mixing tartaric acid with hydrogen
peroxide and a low concentration of a ferrous salt. Full papers in 1894 and 1896 showed the …

Oxidants with free-radical character are wellknown instigators of DNA and RNA damage.
The group includes certain activated antibiotics, metal complexes, redox-active …

“Footprinting” refers to assays that examine ligand binding and conformational changes by
determining the solvent accessibility of the backbone, bases, or side chain structures of …

Recently there has been great interest in designing small metal complexes which are
capable of catalytically hydrolyzing deoxyribonucleic acid (DNA), ribonucleic acid (RNA) …

Publisher Summary This chapter discusses DNA and RNA cleavage by metal complexes.
DNA and RNA cleavage, a very active field of research, has been developed in two main …

Deoxyribonucleic acid (DNA) appears to be a critical cellular target for the biological effects
(cellular lethality, mutagenesis, carcinogenesis, and ageing) of oxidation processes …

The rational design of artificial metallonucleases capable of cleaving DNA in a controllable
manner is highly desired due to their potential application in biology and medicine. This …