The role of liver biopsy in the diagnosis of hepatocellular carcinoma (HCC) has been
challenged over time by the ability of imaging techniques to characterize liver lesions in …

Tumor cells rely on glutamine to fulfill their metabolic demands and sustain proliferation. The
elevated consumption of glutamine can lead to intratumoral nutrient depletion, causing …

Noncoding RNAs (ncRNAs) represent a class of RNA molecules that typically do not code
for proteins. Emerging data suggest that ncRNAs play an important role in several …

Abstract tRNA-derived fragments (tRFs) are a novel class of small non-coding RNAs whose
biological roles are not well defined. Here, using multiple approaches, we investigated its …

Pancreatic ductal adenocarcinoma (PDAC) is highly infiltrated by CD4+ T cells that express
RORγt and IL-17 (TH17). Compelling evidence from the tumor microenvironment suggest …

Background Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality
and metastatic potential, there is a lack of effective therapies and a low survival rate for this …

Background Pancreatic and peri-pancreatic neoplasms encompass a variety of histotypes
characterized by a heterogeneous prognostic impact. miRNAs are considered efficient …

Despite advances in diagnostics, less than 5% of patients with periampullary tumors
experience an overall survival of five years or more. Periampullary tumors are neoplasms …

Background Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due
to late-stage diagnoses resulting from nonspecific early symptoms and the absence of early …

Polycyclic aromatic hydrocarbons (PAHs), particularly benzo [a] pyrene (B [a] P), found in
cigarette smoke and air pollution, is an important carcinogen. Nevertheless, early molecular …