The effects of polyphenols and other bioactives on human health

CG Fraga, KD Croft, DO Kennedy… - Food & function, 2019 - pubs.rsc.org
Although deficiencies in polyphenol intake do not result in specific deficiency diseases,
adequate intake of polyphenols could confer health benefits, especially with regard to …

Health benefits of resveratrol: Evidence from clinical studies

AP Singh, R Singh, SS Verma, V Rai… - Medicinal research …, 2019 - Wiley Online Library
Resveratrol is a polyphenolic nutraceutical that exhibits pleiotropic activities in human
subjects. The efficacy, safety, and pharmacokinetics of resveratrol have been documented in …

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

MS Bonkowski, DA Sinclair - Nature reviews Molecular cell biology, 2016 - nature.com
Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

[HTML][HTML] Pleotropic effects of polyphenols in cardiovascular system

T Behl, S Bungau, K Kumar, G Zengin, F Khan… - Biomedicine & …, 2020 - Elsevier
Numerous epidemiological and clinical studies demonstrate the beneficial effects of
naturally occurring, polyphenol supplementations, on cardiovascular system. The present …

Resveratrol and its human metabolites—effects on metabolic health and obesity

M Springer, S Moco - Nutrients, 2019 - mdpi.com
Resveratrol is one of the most widely studied polyphenols and it has been assigned a
plethora of metabolic effects with potential health benefits. Given its low bioavailability and …

Resveratrol and cardiovascular diseases

D Bonnefont-Rousselot - Nutrients, 2016 - mdpi.com
The increased incidence of cardiovascular diseases (CVDs) has stimulated research for
substances that could improve cardiovascular health. Among them, resveratrol (RES), a …

Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases

D Del Rio, A Rodriguez-Mateos… - Antioxidants & redox …, 2013 - liebertpub.com
Human intervention trials have provided evidence for protective effects of various (poly)
phenol-rich foods against chronic disease, including cardiovascular disease …

[HTML][HTML] Endothelial dysfunction—a major mediator of diabetic vascular disease

CM Sena, AM Pereira, R Seiça - … et Biophysica Acta (BBA)-molecular basis …, 2013 - Elsevier
The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Resveratrol, metabolic syndrome, and gut microbiota

A Chaplin, C Carpéné, J Mercader - Nutrients, 2018 - mdpi.com
Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic
syndrome-related alterations in experimental animals, including glucose and lipid …

[HTML][HTML] The molecular targets of resveratrol

SS Kulkarni, C Cantó - Biochimica et Biophysica Acta (BBA)-Molecular …, 2015 - Elsevier
Resveratrol has emerged in recent years as a compound conferring strong protection
against metabolic, cardiovascular and other age-related complications, including …