[HTML][HTML] Organ-on-a-chip meets artificial intelligence in drug evaluation

S Deng, C Li, J Cao, Z Cui, J Du, Z Fu, H Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

3D-printed hydrogel for diverse applications: A review

A Agrawal, CM Hussain - Gels, 2023 - mdpi.com
Hydrogels have emerged as a versatile and promising class of materials in the field of 3D
printing, offering unique properties suitable for various applications. This review delves into …

Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

D Soto Veliz, KL Lin, C Sahlgren - Smart medicine, 2023 - Wiley Online Library
Current biomedical models fail to replicate the complexity of human biology. Consequently,
almost 90% of drug candidates fail during clinical trials after decades of research and …

Liver-on-a-chip: Considerations, advances, and beyond

Z Yang, X Liu, EM Cribbin, AM Kim, JJ Li, KT Yong - Biomicrofluidics, 2022 - pubs.aip.org
The liver is the largest internal organ in the human body with largest mass of glandular
tissue. Modeling the liver has been challenging due to its variety of major functions …

How organ-on-a-chip technology can assist in studying the role of the glymphatic system in neurodegenerative diseases

S Spitz, E Ko, P Ertl, RD Kamm - International journal of molecular …, 2023 - mdpi.com
The lack of a conventional lymphatic system that permeates throughout the entire human
brain has encouraged the identification and study of alternative clearance routes within the …

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration

JF Hernández-Rodríguez, MÁ López, D Rojas… - Lab on a Chip, 2022 - pubs.rsc.org
Organ on-a-chip (OoC) is a promising technology that aims to recapitulate human body
pathophysiology in a more precise way to advance in drug development and complex …

Facile photopatterning of perfusable microchannels in hydrogels for microphysiological systems

A Mora-Boza, A Mulero-Russe, N Di Caprio… - Nature …, 2025 - nature.com
Perfusable hydrogels have garnered substantial attention in recent years for the fabrication
of microphysiological systems. However, current methodologies to fabricate microchannels …

Cardiac tissue engineering: an emerging approach to the treatment of heart failure

H Rayat Pisheh, FS Nojabaei, A Darvishi… - … in Bioengineering and …, 2024 - frontiersin.org
Heart failure is a major health problem in which the heart is unable to pump enough blood to
meet the body's needs. It is a progressive disease that becomes more severe over time and …

Continuous flow delivery system for the perfusion of scaffold-based 3D cultures

ZR Sitte, EE Karlsson, H Li, H Zhou, MR Lockett - Lab on a Chip, 2024 - pubs.rsc.org
The paper-based culture platform developed by Whitesides readily incorporates tissue-like
structures into laboratories with established workflows that rely on monolayer cultures. Cell …

Microfluidics for 3D cell and tissue cultures: microfabricative and ethical aspects updates

T Limongi, F Guzzi, E Parrotta, P Candeloro, S Scalise… - Cells, 2022 - mdpi.com
The necessity to improve in vitro cell screening assays is becoming ever more important.
Pharmaceutical companies, research laboratories and hospitals require technologies that …