Pathogenic autoantibodies in multiple sclerosis—from a simple idea to a complex concept
R Höftberger, H Lassmann, T Berger… - Nature Reviews …, 2022 - nature.com
The role of autoantibodies in multiple sclerosis (MS) has been enigmatic since the first
description, many decades ago, of intrathecal immunoglobulin production in people with this …
description, many decades ago, of intrathecal immunoglobulin production in people with this …
Origins and immunopathogenesis of autoimmune central nervous system disorders
The field of autoimmune neurology is rapidly evolving, and recent discoveries have
advanced our understanding of disease aetiologies. In this article, we review the key …
advanced our understanding of disease aetiologies. In this article, we review the key …
Analysis of inflammatory markers and tau deposits in an autopsy series of nine patients with anti-IgLON5 disease
E Berger-Sieczkowski, V Endmayr, C Haider… - Acta …, 2023 - Springer
Anti-IgLON5 disease is a rare neurological, probably autoimmune, disorder associated in
many cases with a specific tauopathy. Only a few post-mortem neuropathological studies …
many cases with a specific tauopathy. Only a few post-mortem neuropathological studies …
Antibody therapies in autoimmune encephalitis
I Smets, MJ Titulaer - Neurotherapeutics, 2022 - Springer
Autoimmune encephalitis (AE) comprises a heterogeneous group of disorders in which the
host immune system targets self-antigens expressed in the central nervous system. The …
host immune system targets self-antigens expressed in the central nervous system. The …
[HTML][HTML] Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony
M Ceanga, V Rahmati, H Haselmann, L Schmidl… - Cell reports, 2023 - cell.com
Anti-NMDA receptor autoantibodies (NMDAR-Abs) in patients with NMDAR encephalitis
cause severe disease symptoms resembling psychosis and cause cognitive dysfunction …
cause severe disease symptoms resembling psychosis and cause cognitive dysfunction …
Paraneoplastic cerebellar degeneration with P/Q-VGCC vs Yo autoantibodies
Background and Objectives Paraneoplastic cerebellar degeneration (PCD) is characterized
by a widespread loss of Purkinje cells (PCs) and may be associated with autoantibodies …
by a widespread loss of Purkinje cells (PCs) and may be associated with autoantibodies …
Allosteric modulation of NMDARs reverses patients' autoantibody effects in mice
M Radosevic, J Planagumà, F Mannara… - Neurology …, 2021 - AAN Enterprises
Background and Objectives To demonstrate that an analog (SGE-301) of a brain-derived
cholesterol metabolite, 24 (S)-hydroxycholesterol, which is a selective positive allosteric …
cholesterol metabolite, 24 (S)-hydroxycholesterol, which is a selective positive allosteric …
Chimeric antigen receptor T-cell therapy for autoimmune diseases of the central nervous system: a systematic literature review
AM Konitsioti, H Prüss, S Laurent, GR Fink… - Journal of …, 2024 - Springer
Chimeric antigen receptor T-cell therapy for autoimmune diseases of the central nervous
system: a systematic literature review | Journal of Neurology Skip to main content SpringerLink …
system: a systematic literature review | Journal of Neurology Skip to main content SpringerLink …
In vivo N-Methyl-d-Aspartate receptor (NMDAR) density as assessed using positron emission tomography during recovery from NMDAR-antibody encephalitis
Methods| In this case-control study, we performed cross-sectional resting-state positron
emission tomography (PET) of NMDARs in vivo using radioligand [18F] GE-179, which binds …
emission tomography (PET) of NMDARs in vivo using radioligand [18F] GE-179, which binds …
Therapeutic approach to autoimmune neurologic disorders
SL Clardy, TL Smith - CONTINUUM: Lifelong Learning in …, 2024 - journals.lww.com
OBJECTIVE Autoimmune neurologic disorders encompass a broad category of diseases
characterized by immune system attack of the central, peripheral, or autonomic nervous …
characterized by immune system attack of the central, peripheral, or autonomic nervous …