Pathogenic autoantibodies in multiple sclerosis—from a simple idea to a complex concept

R Höftberger, H Lassmann, T Berger… - Nature Reviews …, 2022 - nature.com
The role of autoantibodies in multiple sclerosis (MS) has been enigmatic since the first
description, many decades ago, of intrathecal immunoglobulin production in people with this …

Origins and immunopathogenesis of autoimmune central nervous system disorders

S Ramanathan, F Brilot, SR Irani, RC Dale - Nature Reviews Neurology, 2023 - nature.com
The field of autoimmune neurology is rapidly evolving, and recent discoveries have
advanced our understanding of disease aetiologies. In this article, we review the key …

Analysis of inflammatory markers and tau deposits in an autopsy series of nine patients with anti-IgLON5 disease

E Berger-Sieczkowski, V Endmayr, C Haider… - Acta …, 2023 - Springer
Anti-IgLON5 disease is a rare neurological, probably autoimmune, disorder associated in
many cases with a specific tauopathy. Only a few post-mortem neuropathological studies …

Antibody therapies in autoimmune encephalitis

I Smets, MJ Titulaer - Neurotherapeutics, 2022 - Springer
Autoimmune encephalitis (AE) comprises a heterogeneous group of disorders in which the
host immune system targets self-antigens expressed in the central nervous system. The …

[HTML][HTML] Human NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony

M Ceanga, V Rahmati, H Haselmann, L Schmidl… - Cell reports, 2023 - cell.com
Anti-NMDA receptor autoantibodies (NMDAR-Abs) in patients with NMDAR encephalitis
cause severe disease symptoms resembling psychosis and cause cognitive dysfunction …

Paraneoplastic cerebellar degeneration with P/Q-VGCC vs Yo autoantibodies

M Winklehner, J Bauer, V Endmayr… - Neurology …, 2022 - AAN Enterprises
Background and Objectives Paraneoplastic cerebellar degeneration (PCD) is characterized
by a widespread loss of Purkinje cells (PCs) and may be associated with autoantibodies …

Allosteric modulation of NMDARs reverses patients' autoantibody effects in mice

M Radosevic, J Planagumà, F Mannara… - Neurology …, 2021 - AAN Enterprises
Background and Objectives To demonstrate that an analog (SGE-301) of a brain-derived
cholesterol metabolite, 24 (S)-hydroxycholesterol, which is a selective positive allosteric …

Chimeric antigen receptor T-cell therapy for autoimmune diseases of the central nervous system: a systematic literature review

AM Konitsioti, H Prüss, S Laurent, GR Fink… - Journal of …, 2024 - Springer
Chimeric antigen receptor T-cell therapy for autoimmune diseases of the central nervous
system: a systematic literature review | Journal of Neurology Skip to main content SpringerLink …

In vivo N-Methyl-d-Aspartate receptor (NMDAR) density as assessed using positron emission tomography during recovery from NMDAR-antibody encephalitis

M Galovic, A Al-Diwani, U Vivekananda… - JAMA …, 2023 - jamanetwork.com
Methods| In this case-control study, we performed cross-sectional resting-state positron
emission tomography (PET) of NMDARs in vivo using radioligand [18F] GE-179, which binds …

Therapeutic approach to autoimmune neurologic disorders

SL Clardy, TL Smith - CONTINUUM: Lifelong Learning in …, 2024 - journals.lww.com
OBJECTIVE Autoimmune neurologic disorders encompass a broad category of diseases
characterized by immune system attack of the central, peripheral, or autonomic nervous …