Cellular agriculture, that is, the cell culture-based production of food, may provide an
alternative to traditional farming, minimizing the environmental effect, while ensuring …

During the past five years, the number of single‐use bioreactors used in biopharmaceutical
research and production has increased tremendously. This increase has been particularly …

The use of hMSCs for allogeneic therapies requiring lot sizes of billions of cells will
necessitate large-scale culture techniques such as the expansion of cells on microcarriers in …

Bioreactor process parameters influence the N-linked glycosylation profile of the produced
monoclonal antibodies. A systematic assessment of their impact is a prerequisite for …

There is a growing body of evidence that the ambr™ workstation from TAP Biosystems
performs well in terms of helping to select appropriate clones for scale-up studies. Here we …

Transfer of mammalian cell culture processes across stirred and aerated bioreactor scales is
a delicate task, frequently leading to different conditions across scales. To provide a more …

Gas dispersion in non‐Newtonian fluids is a challenging task due to the formation of large
cavities behind the impeller blades, which leads to the generation of very large bubbles. In …

The emergence of cell and gene therapies has generated significant interest in their clinical
and commercial potential. However, these therapies are prohibitively expensive to …

In conventional stirred and aerated tank bioreactors, the choice of impeller type and
configuration is critical to ensure suitable hydrodynamic conditions that maximize oxygen …

The objective of this study was to develop a Scale-Down Model of a hydrodynamic stress
present in large scale production bioreactors to investigate the performance of CHO cells …