The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐
like peptide‐1 (GLP‐1) have their main physiological role in augmenting insulin secretion …

Gut hormones have many key roles in the control of metabolism, as they target diverse
tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation …

In addition to their bioenergetic intracellular function, several classical metabolites act as
extracellular signaling molecules activating cell-surface G-protein-coupled receptors …

Background The positive influences of glucagon-like peptide-1 (GLP-1) on blood glucose
homeostasis, appetite sensations, and food intake provide a strong rationale for its …

The gastrointestinal tract can assess the nutrient composition of ingested food. The nutrient-
sensing mechanisms in specialised epithelial cells lining the gastrointestinal tract, the …

The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

The gastrointestinal tract hosts the largest ecosystem of microorganisms in the body. The
metabolism of ingested nutrients by gut bacteria produces novel chemical mediators that …

The aim of this study was to explore individual amino acid-stimulated GLP-1 responses and
the underlying stimulatory mechanisms, as well as to identify the amino acid-sensing …

The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon
like peptide-1 (GLP-1) are secreted from enteroendocrine cells in the gut and regulate …

Diabetes, a glucose metabolic disorder, is considered one of the biggest challenges
associated with a complex complication of health crises in the modern lifestyle. Inhibition or …