Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Biophysical signals act as potent regulators of stem cell function, lineage commitment, and
epigenetic status. In recent years, synthetic biomaterials have been used to study a wide …

In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix
are associated with cellular de-differentiation and with subsequent functional declines …

In order to achieve consistent and predictable fracture healing, a broad spectrum of growth
factors are required to interact with one another in a highly organized response. Critically …

Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue
engineering and regenerative medicine, and are understood to be mechanosensitive to …

The nucleus has long been postulated to play a critical physical role during cell polarization
and migration, but that role has not been defined or rigorously tested. Here, we enucleated …

Achieving functional restoration of diseased or injured tissues is the ultimate goal of both
regenerative medicine approaches and physical therapy interventions. Proper integration …

Many signaling pathways converge on the nucleus to regulate crucial nuclear events such
as transcription, DNA replication and cell cycle progression. Although the vast majority of …

Cells live in a complex and dynamic microenvironment, and a variety of microenvironmental
cues can regulate cell behavior. In addition to biochemical signals, biophysical cues can …

Actin structure contributes to physiologic events within the nucleus to control mesenchymal
stromal cell (MSC) differentiation. Continuous cytochalasin D (Cyto D) disruption of the MSC …