To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?

MU Shiloh, PADG Champion - Current opinion in microbiology, 2010 - Elsevier
Mycobacterium tuberculosis is the causative agent of the global tuberculosis epidemic. To
combat this successful human pathogen we need a better understanding of the basic …

Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design

KC Ferrell, MD Johansen, JA Triccas… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium abscessus is a member of the non-tuberculous mycobacteria (NTM) group,
responsible for chronic infections in individuals with cystic fibrosis (CF) or those otherwise …

Local delivery of gaseous signaling molecules for orthopedic disease therapy

J Sun, W Wang, X Hu, X Zhang, C Zhu, J Hu… - Journal of …, 2023 - Springer
Over the past decade, a proliferation of research has used nanoparticles to deliver gaseous
signaling molecules for medical purposes. The discovery and revelation of the role of …

Common patterns–unique features: nitrogen metabolism and regulation in Gram-positive bacteria

J Amon, F Titgemeyer… - FEMS microbiology …, 2010 - academic.oup.com
Gram-positive bacteria have developed elaborate mechanisms to control ammonium
assimilation, at the levels of both transcription and enzyme activity. In this review, the …

Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages

A Speer, J Sun, O Danilchanka, V Meikle… - Molecular …, 2015 - Wiley Online Library
Sphingomyelinases secreted by pathogenic bacteria play important roles in host–pathogen
interactions ranging from interfering with phagocytosis and oxidative burst to iron …

Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin‐derived peptides

GE Purdy, M Niederweis, DG Russell - Molecular microbiology, 2009 - Wiley Online Library
Ubiquitin‐derived peptides are bactericidal in vitro and contribute to the mycobactericidal
activity of the lysosome. To further define interactions of ubiquitin‐derived peptides with …

The Mycobacterium tuberculosis outer membrane channel protein CpnT confers susceptibility to toxic molecules

O Danilchanka, D Pires, E Anes… - Antimicrobial Agents …, 2015 - Am Soc Microbiol
Mycobacterium tuberculosis, the causative agent of tuberculosis, is protected from toxic
solutes by an effective outer membrane permeability barrier. Recently, we showed that the …

[HTML][HTML] A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis

Y Yang, K Kulka, RC Montelaro, TA Reinhart… - Cell host & …, 2014 - cell.com
Chronic tuberculosis in an immunocompetent host is a consequence of the delicately
balanced growth of Mycobacterium tuberculosis (Mtb) in the face of host defense …

Genetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients

A Lewin, E Kamal, T Semmler, K Winter, S Kaiser… - Virulence, 2021 - Taylor & Francis
Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a
deterioration of lung function. Treatment of these multidrug-resistant pathogens is …

A FRET-based fluorogenic trehalose dimycolate analogue for probing mycomembrane-remodeling enzymes of mycobacteria

NJ Holmes, HW Kavunja, Y Yang, BD Vannest… - ACS …, 2019 - ACS Publications
The mycobacterial outer membrane, or mycomembrane, is essential for the viability and
virulence of Mycobacterium tuberculosis and related pathogens. The mycomembrane is a …