To catch a killer. What can mycobacterial models teach us about Mycobacterium tuberculosis pathogenesis?
MU Shiloh, PADG Champion - Current opinion in microbiology, 2010 - Elsevier
Mycobacterium tuberculosis is the causative agent of the global tuberculosis epidemic. To
combat this successful human pathogen we need a better understanding of the basic …
combat this successful human pathogen we need a better understanding of the basic …
Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design
KC Ferrell, MD Johansen, JA Triccas… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium abscessus is a member of the non-tuberculous mycobacteria (NTM) group,
responsible for chronic infections in individuals with cystic fibrosis (CF) or those otherwise …
responsible for chronic infections in individuals with cystic fibrosis (CF) or those otherwise …
Local delivery of gaseous signaling molecules for orthopedic disease therapy
Over the past decade, a proliferation of research has used nanoparticles to deliver gaseous
signaling molecules for medical purposes. The discovery and revelation of the role of …
signaling molecules for medical purposes. The discovery and revelation of the role of …
Common patterns–unique features: nitrogen metabolism and regulation in Gram-positive bacteria
J Amon, F Titgemeyer… - FEMS microbiology …, 2010 - academic.oup.com
Gram-positive bacteria have developed elaborate mechanisms to control ammonium
assimilation, at the levels of both transcription and enzyme activity. In this review, the …
assimilation, at the levels of both transcription and enzyme activity. In this review, the …
Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages
Sphingomyelinases secreted by pathogenic bacteria play important roles in host–pathogen
interactions ranging from interfering with phagocytosis and oxidative burst to iron …
interactions ranging from interfering with phagocytosis and oxidative burst to iron …
Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin‐derived peptides
GE Purdy, M Niederweis, DG Russell - Molecular microbiology, 2009 - Wiley Online Library
Ubiquitin‐derived peptides are bactericidal in vitro and contribute to the mycobactericidal
activity of the lysosome. To further define interactions of ubiquitin‐derived peptides with …
activity of the lysosome. To further define interactions of ubiquitin‐derived peptides with …
The Mycobacterium tuberculosis outer membrane channel protein CpnT confers susceptibility to toxic molecules
Mycobacterium tuberculosis, the causative agent of tuberculosis, is protected from toxic
solutes by an effective outer membrane permeability barrier. Recently, we showed that the …
solutes by an effective outer membrane permeability barrier. Recently, we showed that the …
[HTML][HTML] A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis
Y Yang, K Kulka, RC Montelaro, TA Reinhart… - Cell host & …, 2014 - cell.com
Chronic tuberculosis in an immunocompetent host is a consequence of the delicately
balanced growth of Mycobacterium tuberculosis (Mtb) in the face of host defense …
balanced growth of Mycobacterium tuberculosis (Mtb) in the face of host defense …
Genetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients
Mycobacterium (M.) abscessus infections in Cystic Fibrosis (CF) patients cause a
deterioration of lung function. Treatment of these multidrug-resistant pathogens is …
deterioration of lung function. Treatment of these multidrug-resistant pathogens is …
A FRET-based fluorogenic trehalose dimycolate analogue for probing mycomembrane-remodeling enzymes of mycobacteria
NJ Holmes, HW Kavunja, Y Yang, BD Vannest… - ACS …, 2019 - ACS Publications
The mycobacterial outer membrane, or mycomembrane, is essential for the viability and
virulence of Mycobacterium tuberculosis and related pathogens. The mycomembrane is a …
virulence of Mycobacterium tuberculosis and related pathogens. The mycomembrane is a …