The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral
development and progression both in solid cancers and hematological malignancies. The …

Abstract The P2X receptor 7 (P2X7R) is a plasma membrane receptor sensing extracellular
ATP associated with a wide variety of cellular functions. It is most commonly expressed on …

Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as
microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor …

Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation
and an important factor for immune regulation. The purine de novo pathway and salvage …

Breast cancer is currently the most common cancer and the leading cause of cancer death
among women worldwide. Advanced breast cancer is prone to metastasis, and there is …

The tumor niche is an environment rich in extracellular ATP (eATP) where purinergic
receptors have essential roles in different cell subtypes, including cancer, immune, and …

Glioblastomas are highly aggressive and deadly brain tumours, with a median survival time
of 14–18 months post-diagnosis. Current treatment modalities are limited and only modestly …

Triple negative breast cancer (TNBC) is a subtype of breast tumor characterized for the
absence of estrogen and progesterone receptors expression and low HER2/neu expression …

The heterogeneity of tumor cell mass and the plasticity of cancer cell phenotypes in solid
tumors allow for the insurgence of resistant and metastatic cells, responsible for cancer …

Cancer pain is the most prevalent symptom experienced by cancer patients. It substantially
impacts a patient's long-term physical and emotional health, making it a pressing issue that …