Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The
treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy …
treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy …
Colchicine alkaloids and synthetic analogues: current progress and perspectives
IA Gracheva, ES Shchegravina… - Journal of medicinal …, 2020 - ACS Publications
Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural
molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its …
molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its …
Potential anticancer role of colchicine-based derivatives: an overview
A Kumar, PR Sharma, DM Mondhe - Anti-cancer drugs, 2017 - journals.lww.com
Colchicine, the main alkaloid of the poisonous plant meadow saffron (Colchicum autumnale
L.), is a classical drug used for the treatment of gout and familial Mediterranean fever …
L.), is a classical drug used for the treatment of gout and familial Mediterranean fever …
Piperazine skeleton in the structural modification of natural products: a review
RH Zhang, HY Guo, H Deng, J Li… - Journal of enzyme …, 2021 - Taylor & Francis
Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …
ABC transporters: regulation and association with multidrug resistance in hepatocellular carcinoma and colorectal carcinoma
MP Ceballos, JP Rigalli, LI Ceré… - Current medicinal …, 2019 - ingentaconnect.com
For most cancers, the treatment of choice is still chemotherapy despite its severe adverse
effects, systemic toxicity and limited efficacy due to the development of multidrug resistance …
effects, systemic toxicity and limited efficacy due to the development of multidrug resistance …
Novel natural product-and privileged scaffold-based tubulin inhibitors targeting the colchicine binding site
M Dong, F Liu, H Zhou, S Zhai, B Yan - Molecules, 2016 - mdpi.com
Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the
use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side …
use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side …
Tubulin inhibitors binding to colchicine-site: a review from 2015 to 2019
LY Xia, YL Zhang, R Yang, ZC Wang… - Current medicinal …, 2020 - ingentaconnect.com
Due to the three domains of the colchicine-site which is conducive to the combination with
small molecule compounds, colchicine-site on the tubulin has become a common target for …
small molecule compounds, colchicine-site on the tubulin has become a common target for …
Antiproliferative potential of gloriosine: A lead for anticancer drug development
Gloriosine, a colchicine-like natural product, is widely obtained from Gloriosa superba roots.
Despite having remarkable anticancer potential, colchicine could not pave its way to the …
Despite having remarkable anticancer potential, colchicine could not pave its way to the …
Apoptotic Potential and Antitumor Efficacy of Trilliumoside A: A New Steroidal Saponin Isolated from Rhizomes of Trillium govanianum
M Tabassum, BA Lone, MN Bhat, A Bhushan… - ACS …, 2023 - ACS Publications
Natural product-derived molecules exhibit potential as anticancer agents. Trilliumoside A, a
new steroidal saponin, was obtained from rhizomes of Trillium govanianum, and its …
new steroidal saponin, was obtained from rhizomes of Trillium govanianum, and its …
Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
AA Ghawanmeh, HM Al-Bajalan, MM Mackeen… - European journal of …, 2020 - Elsevier
Colchicine, an anti-microtubulin polymerization agent, is a valuable medication and the drug
of choice for gout, Behçet's disease and familial Mediterranean fever. It has a narrow …
of choice for gout, Behçet's disease and familial Mediterranean fever. It has a narrow …