Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The
treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy …

Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural
molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its …

Colchicine, the main alkaloid of the poisonous plant meadow saffron (Colchicum autumnale
L.), is a classical drug used for the treatment of gout and familial Mediterranean fever …

Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

For most cancers, the treatment of choice is still chemotherapy despite its severe adverse
effects, systemic toxicity and limited efficacy due to the development of multidrug resistance …

Tubulin inhibitors are effective anticancer agents, however, there are many limitations to the
use of available tubulin inhibitors in the clinic, such as multidrug resistance, severe side …

Due to the three domains of the colchicine-site which is conducive to the combination with
small molecule compounds, colchicine-site on the tubulin has become a common target for …

Gloriosine, a colchicine-like natural product, is widely obtained from Gloriosa superba roots.
Despite having remarkable anticancer potential, colchicine could not pave its way to the …

Natural product-derived molecules exhibit potential as anticancer agents. Trilliumoside A, a
new steroidal saponin, was obtained from rhizomes of Trillium govanianum, and its …

Colchicine, an anti-microtubulin polymerization agent, is a valuable medication and the drug
of choice for gout, Behçet's disease and familial Mediterranean fever. It has a narrow …