The synthesis of vitellogenin and its uptake by maturing oocytes during egg maturation are
essential for successful female reproduction. These events are regulated by the juvenile …

Immune defense and reproduction are physiologically and energetically demanding
processes and have been observed to trade off in a diversity of female insects. Increased …

Advances in metabolomics have deepened our understanding of the roles that specific
modes of metabolism play in programming stem cell fates. Here, we review recent …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

Diabetes, a metabolic disorder of glucose, is a serious chronic disease and an important
public health problem. Insulin is one of the hormones for modulating blood glucose level …

Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …

Central and peripheral insulin-like peptides (ILPs), which include insulin, insulin-like growth
factor 1 (IGF1) and IGF2, exert many effects in the brain. Through their actions on brain …

Drosophila melanogaster has been a key model in developing our current understanding of
the molecular mechanisms of ageing. Of particular note is its role in establishing the …

Sexually dimorphic mammalian tissues, including sexual organs and the brain, contain stem
cells that are directly or indirectly regulated by sex hormones,,,,,. An important question is …

Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …