Enzymes and mechanisms employed by tailed bacteriophages to breach the bacterial cell barriers

S Fernandes, C São-José - Viruses, 2018 - mdpi.com
Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell
wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the …

Learning from bacteriophages-advantages and limitations of phage and phage-encoded protein applications

Z Drulis-Kawa, G Majkowska-Skrobek… - Current Protein and …, 2012 - ingentaconnect.com
The emergence of bacteria resistance to most of the currently available antibiotics has
become a critical therapeutic problem. The bacteria causing both hospital and community …

Diversity in bacterial lysis systems: bacteriophages show the way

MJ Catalao, F Gil, J Moniz-Pereira… - FEMS microbiology …, 2013 - academic.oup.com
Bacteriophages have developed multiple host cell lysis strategies to promote release of
descendant virions from infected bacteria. This review is focused on the lysis mechanisms …

Enzybiotics: Enzyme-based antibacterials as therapeutics

D Dams, Y Briers - Therapeutic enzymes: Function and clinical …, 2019 - Springer
Antibiotics have saved millions of lives. However, the overuse and misuse of antibiotics have
contributed to a rapid emergence of antibiotic resistance worldwide. In addition, there is an …

Phage therapy as a renewed therapeutic approach to mycobacterial infections: a comprehensive review

T Azimi, M Mosadegh, MJ Nasiri, S Sabour… - Infection and Drug …, 2019 - Taylor & Francis
Mycobacterial infections are considered to a serious challenge of medicine, and the
emergence of MDR and XDR tuberculosis is a serious public health problem. Tuberculosis …

From endolysins to Artilysin® s: novel enzyme-based approaches to kill drug-resistant bacteria

H Gerstmans, L Rodríguez-Rubio… - Biochemical Society …, 2016 - portlandpress.com
One of the last untapped reservoirs in nature for the identification of new anti-microbials is
bacteriophages, the natural killers of bacteria. Lytic bacteriophages encode peptidoglycan …

Phage‐based technologies for highly sensitive luminescent detection of foodborne pathogens and microbial toxins: A review

J Ye, J Guo, T Li, J Tian, M Yu, X Wang… - … Reviews in Food …, 2022 - Wiley Online Library
Foodborne pathogens and microbial toxins are the main causes of foodborne illness.
However, trace pathogens and toxins in foods are difficult to detect. Thus, techniques for …

Mycobacteriophage endolysins: diverse and modular enzymes with multiple catalytic activities

KM Payne, GF Hatfull - PLoS One, 2012 - journals.plos.org
The mycobacterial cell wall presents significant challenges to mycobacteriophages–viruses
that infect mycobacterial hosts–because of its unusual structure containing a mycolic acid …

Recombineering: A powerful tool for modification of bacteriophage genomes

LJ Marinelli, GF Hatfull, M Piuri - Bacteriophage, 2012 - Taylor & Francis
Recombineering, a recently developed technique for efficient genetic manipulation of
bacteria, is facilitated by phage-derived recombination proteins and has the advantage of …

Looking beyond typical treatments for atypical mycobacteria

CM Bento, MS Gomes, T Silva - Antibiotics, 2020 - mdpi.com
The genus Mycobacterium comprises not only the deadliest of bacterial pathogens,
Mycobacterium tuberculosis, but several other pathogenic species, including M. avium and …