Immune checkpoint inhibitors in hepatocellular carcinoma: opportunities and challenges

X Liu, S Qin - The oncologist, 2019 - academic.oup.com
Hepatocellular carcinoma (HCC) is the most common malignancy worldwide, and is
especially common in China. A total of 70%–80% of patients are diagnosed at an advanced …

ABC transporters: regulation and association with multidrug resistance in hepatocellular carcinoma and colorectal carcinoma

MP Ceballos, JP Rigalli, LI Ceré… - Current medicinal …, 2019 - ingentaconnect.com
For most cancers, the treatment of choice is still chemotherapy despite its severe adverse
effects, systemic toxicity and limited efficacy due to the development of multidrug resistance …

[HTML][HTML] Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug …

S Saber, M Nasr, AS Saad, AAE Mourad… - Biomedicine & …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. It
was suggested that albendazole (ABZ) is a powerful inhibitor of several carcinoma types …

MDM2-NFAT1 dual inhibitor, MA242: Effective against hepatocellular carcinoma, independent of p53

W Wang, JW Cheng, JJ Qin, B Hu, X Li, B Nijampatnam… - Cancer letters, 2019 - Elsevier
The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma
(HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type …

[HTML][HTML] Mechanisms of resistance to chemotherapy and radiotherapy in hepatocellular carcinoma

J Guo, L Li, B Guo, D Liu, J Shi, C Wu… - Translational Cancer …, 2018 - tcr.amegroups.org
Hepatocellular carcinoma (HCC) is an inflammation-related malignant tumor that develops
from underlying cirrhosis. As HCC is a common tumor seen in clinical practice, its prevention …

Carnosic acid induces apoptosis of hepatocellular carcinoma cells via ROS-mediated mitochondrial pathway

X Zhang, Y Chen, G Cai, X Li, D Wang - Chemico-Biological Interactions, 2017 - Elsevier
Carnosic acid (CA), an important bioactive phenolic diterpene mainly found in labiate plants,
exerts various biological functions, including antioxidant, anti-inflammatory, antitumor, and …

[HTML][HTML] A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance

W Wang, B Hu, JJ Qin, JW Cheng, X Li, M Rajaei… - Genes & …, 2019 - Elsevier
Overexpression of the MDM2 oncogene and mutations in the p53 tumor suppressor
commonly occur in hepatocellular carcinoma (HCC) and are associated with increased …

Telmisartan attenuates N-nitrosodiethylamine-induced hepatocellular carcinoma in mice by modulating the NF-κB-TAK1-ERK1/2 axis in the context of PPARγ …

S Saber, AE Khodir, WE Soliman, MM Salama… - Naunyn-Schmiedeberg's …, 2019 - Springer
Hepatocellular carcinoma (HCC) is characterized by bad prognosis and is the second most
common reason for cancer-linked mortality. Treatment with sorafenib (SRF) alone increases …

Diagnostic accuracy of serum derived exosomes for hepatocellular carcinoma: A systematic review and meta-analysis

A Tiyuri, SS Baghermanesh… - Expert review of …, 2023 - Taylor & Francis
Introduction Early and non-invasive detection of hepatocellular carcinoma (HCC), which is
usually asymptomatic, can improve overall survival outcomes. The objective of this …

miRNA‑346 promotes proliferation, migration and invasion in liver cancer

Q Yu, X Yang, W Duan, C Li, Y Luo… - Oncology …, 2017 - spandidos-publications.com
Liver cancer primarily accounts for the majority of malignancies of the liver. MicroRNAs
(miRNAs) are endogenous non‑coding RNAs, which are important in tumorigenesis …