Biliary tract cancers (cholangiocarcinomas and gallbladder cancers) are increasing in
incidence and have a poor prognosis. Most patients present with advanced disease, for …

Cholangiocarcinomas (CCAs) are rare but aggressive tumours of the bile ducts, which are
often diagnosed at an advanced stage and have poor outcomes on systemic therapy …

Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …

FGFR signaling is deregulated in many human cancers, and FGFR is considered a valid
target in FGFR-deregulated tumors. Here, we examine the preclinical profile of futibatinib …

FGFR2 rearrangements resulting in dysregulated signaling are drivers of
cholangiocarcinoma (CCA) tumorigenesis, and occur almost exclusively in intrahepatic …

Cholangiocarcinoma (CCA) is a heterogeneous group of neoplasms of the bile ducts and
represents the second most common hepatic cancer after hepatocellular carcinoma; it is sub …

ABSTRACT Introduction Biliary tract cancers (BTCs) are poor prognosis malignancies
usually classified in intrahepatic cholangiocarcinoma (iCCA), extrahepatic …

Cholangiocarcinoma (CCA) includes a heterogeneous group of malignancies with limited
treatment options. Despite recent advances in medical oncology, the prognosis of CCA …

Biliary tract cancers (BTCs) are a heterogeneous group of adenocarcinomas that originate
from the epithelial lining of the biliary tree. BTCs are characterized by presentation with …

Fibroblast growth factor receptor (FGFR) tyrosine kinases, which are expressed on the cell
membrane, are involved in a wide range of biological functions such as cell proliferation …