Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Metrics of sleep apnea severity: beyond the apnea-hypopnea index

A Malhotra, I Ayappa, N Ayas, N Collop, D Kirsch… - Sleep, 2021 - academic.oup.com
Obstructive sleep apnea (OSA) is thought to affect almost 1 billion people worldwide. OSA
has well established cardiovascular and neurocognitive sequelae, although the optimal …

Global burden of sleep‐disordered breathing and its implications

MM Lyons, NY Bhatt, AI Pack, UJ Magalang - Respirology, 2020 - Wiley Online Library
One‐seventh of the world's adult population, or approximately one billion people, are
estimated to have OSA. Over the past four decades, obesity, the main risk factor for OSA, has …

Therapeutic potential of intermittent hypoxia: a matter of dose

A Navarrete-Opazo, GS Mitchell - American Journal of …, 2014 - journals.physiology.org
Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

Oxidative & nitrosative stress in depression: why so much stress?

S Moylan, M Berk, OM Dean, Y Samuni… - Neuroscience & …, 2014 - Elsevier
Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the
pathophysiology of unipolar and bipolar depression. These disorders are characterized inter …

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2

NR Prabhakar, GL Semenza - Physiological reviews, 2012 - journals.physiology.org
Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological
systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of …

Obstructive sleep apnea and severe maternal-infant morbidity/mortality in the United States, 1998-2009

JM Louis, MF Mogos, JL Salemi, S Redline, HM Salihu - Sleep, 2014 - academic.oup.com
Study Objectives: A recent trend in increasing rates of severe maternal morbidity and
mortality despite quality improvements has been noted. The goal of this study is to estimate …

[HTML][HTML] Clinical problems caused by obesity

I Kyrou, HS Randeva, C Tsigos, G Kaltsas… - 2015 - europepmc.org
4. Dr. Gregory Kaltsas MD FRCP (Lon) is a Professor in General Medicine and
Endocrinology at the National and Kapodistrian University of Athens, Greece. He was …

Effect of sleep disturbances on blood pressure

N Makarem, C Alcántara, N Williams, NA Bello… - …, 2021 - Am Heart Assoc
This review summarizes recent literature addressing the association of short sleep duration,
shift work, and obstructive sleep apnea with hypertension risk, blood pressure (BP) levels …

Sleep-related breathing and sleep-wake disturbances in ischemic stroke

DM Hermann, CL Bassetti - Neurology, 2009 - AAN Enterprises
Background: Sleep-related breathing disturbances (SDB) and sleep-wake disturbances
(SWD) are often neglected in stroke patients. Recent studies suggest that they are frequent …