The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation,
histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide …

Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs
cellular shape and function changes throughout tissue development and embryogenesis. In …

β-enolase (ENO3) is a metalloenzyme that functions during glycolysis and has been
revealed ectopic expression in different cancers. However, the function and underlying …

Metastasis is considered as the major cause of cancer death. Cancer cells can be released
from primary tumors into the circulation and then colonize in distant organs. How cancer …

Background In recent years, the role of altered cellular metabolism in tumor progression has
attracted widespread attention. Related metabolic enzymes have also been considered as …

The metabolic enzymes involved in one-carbon metabolism are closely associated with
tumor progression and could be potential targets for cancer therapy. Recent studies showed …

Introduction. Serine hydroxymethyltransferase 2 (SHMT2) has a critical role in serine‐
glycine metabolism to drive cancer cell proliferation. Yet, the function of SHMT2 in …

Serine and glycine are the primary sources of one-carbon units that are vital for cell
proliferation. Their abnormal metabolism is known to be associated with cancer progression …

A high number of cancer-related deaths (up to 90) are due to metastasis and simple
definition of metastasis is new colony formation of tumor cells in a secondary site. In tumor …