Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

The genetic basis for combined pituitary hormone deficiency (CPHD) is complex, involving
30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of …

This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

Combined pituitary hormone deficiency (CPHD) has been linked with rare abnormalities in
genes encoding transcription factors necessary for pituitary development 1. We have …

We have previously shown that familial septo-optic dysplasia (SOD), a syndromic form of
congenital hypopituitarism involving optic nerve hypoplasia and agenesis of midline brain …

POU domain factors are transcriptional regulators characterized by a highly conserved DNA-
binding domain referred to as the POU domain. The structure of the POU domain has been …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis.
The development of the pituitary gland depends on the sequential temporal and spatial …

Diagnosis of growth hormone deficiency in childhood : Current Opinion in Endocrinology,
Diabetes and Obesity Diagnosis of growth hormone deficiency in childhood : Current Opinion in …

Puberty is the period of transition from childhood to adulthood characterized by the
attainment of adult height and body composition, accrual of bone strength and the …

Pituitary gland commitment from oral ectoderm occurs in response to inductive signals from
the neuroepithelium of the ventral diencephalon. Invagination of the oral ectoderm leads to …