The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

INTRODUCTION The ability to regenerate retinal neurons after injury varies drastically
among vertebrate species. Teleost fish such as zebrafish can regenerate all major retinal …

Direct neuronal reprogramming is a promising approach to regenerate neurons from local
glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this …

Neuroendocrine prostate cancer (NEPC), a lethal form of the disease, is characterized by
loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, which …

Minimal sets of transcription factors can directly reprogram somatic cells into neurons.
However, epigenetic remodeling during neuronal reprogramming has not been well …

Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …

Developmental programs that generate the astonishing neuronal diversity of the nervous
system are not completely understood and thus present a major challenge for clinical …

The ability to directly reprogram mature cells to alternative fates challenges concepts of how
cell identities are maintained, erased, and acquired. Recent advances in understanding and …