Antibody therapies for the prevention and treatment of viral infections
Antibodies are an important component in host immune responses to viral pathogens.
Because of their unique maturation process, antibodies can evolve to be highly specific to …
Because of their unique maturation process, antibodies can evolve to be highly specific to …
Recent advances in therapeutic applications of neutralizing antibodies for virus infections: an overview
Antibodies are considered as an excellent foundation to neutralize pathogens and as highly
specific therapeutic agents. Antibodies are generated in response to a vaccine but little use …
specific therapeutic agents. Antibodies are generated in response to a vaccine but little use …
[HTML][HTML] Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
KM Cirelli, DG Carnathan, B Nogal, JT Martin… - Cell, 2019 - cell.com
Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses
Nanoparticles for multivalent display and delivery of vaccine antigens have emerged as a
promising avenue for enhancing B cell responses to protein subunit vaccines. Here, we …
promising avenue for enhancing B cell responses to protein subunit vaccines. Here, we …
De novo protein design enables the precise induction of RSV-neutralizing antibodies
INTRODUCTION The ultimate goal of de novo protein design is to create proteins endowed
with new biological functions. From a structural perspective, this remains a challenge …
with new biological functions. From a structural perspective, this remains a challenge …
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants that evade immunity elicited by vaccination has placed an imperative on the …
variants that evade immunity elicited by vaccination has placed an imperative on the …
Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses
F Hellgren, A Cagigi, R Arcoverde Cerveira… - Nature …, 2023 - nature.com
Licensed rabies virus vaccines based on whole inactivated virus are effective in humans.
However, there is a lack of detailed investigations of the elicited immune response, and …
However, there is a lack of detailed investigations of the elicited immune response, and …
Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on the Middle East respiratory syndrome coronavirus spike glycoprotein to avoid …
Middle East respiratory syndrome coronavirus (MERS-CoV) causes a highly lethal
pulmonary infection with∼ 35% mortality. The potential for a future pandemic originating …
pulmonary infection with∼ 35% mortality. The potential for a future pandemic originating …
[HTML][HTML] Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses
SM Moin, JC Boyington, S Boyoglu-Barnum… - Immunity, 2022 - cell.com
Current influenza vaccines predominantly induce immunity to the hypervariable
hemagglutinin (HA) head, requiring frequent vaccine reformulation. Conversely, the …
hemagglutinin (HA) head, requiring frequent vaccine reformulation. Conversely, the …
Antibody lineages with vaccine-induced antigen-binding hotspots develop broad HIV neutralization
The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1
strains has been a long-standing goal. To understand how broadly neutralizing antibodies …
strains has been a long-standing goal. To understand how broadly neutralizing antibodies …