[HTML][HTML] Evidence for the benefits of melatonin in cardiovascular disease
The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …
Hypotensive effects of melatonin in rats: Focus on the model, measurement, application, and main mechanisms
D Cvikova, H Sutovska, K Babarikova… - Hypertension Research, 2022 - nature.com
The hypotensive effects of melatonin are based on a negative correlation between
melatonin levels and blood pressure in humans. However, there is a positive correlation in …
melatonin levels and blood pressure in humans. However, there is a positive correlation in …
Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats
Valproic acid (VPA) is a anticonvulsant and mood-stabilizing agent used to treat epilepsy in
patients of all ages. However, it can cause hepatotoxicity with increased oxidative stress …
patients of all ages. However, it can cause hepatotoxicity with increased oxidative stress …
The role of melatonin in oxidative stress, DNA damage, apoptosis and angiogenesis in fetal eye under preeclampsia and melatonin deficiency stress
ZB Doğanlar, H Güçlü, Ö Öztopuz, H Türkön… - Current Eye …, 2019 - Taylor & Francis
Aim: The aim of this study was to investigate the possible mechanisms of ocular damage
induced by pinealectomy (PNX) and preeclampsia (PE), and to determine the cellular and …
induced by pinealectomy (PNX) and preeclampsia (PE), and to determine the cellular and …
Effects of melatonin on blood pressure, oxidative stress and placental expressions of TNFα, IL-6, VEGF and sFlt-1 in RUPP rat model of preeclampsia
M Uzun, M Gencer, H Turkon, RO Oztopuz… - Archives of medical …, 2017 - Elsevier
Preeclampsia (PE) is known as a major cause of maternal and neonatal morbidity and
mortality. Maternal hypertension, proteinuria, placental dysfunction and imbalance of …
mortality. Maternal hypertension, proteinuria, placental dysfunction and imbalance of …
Melatonin attenuates chemical-induced cardiotoxicity
S Zare, FS Heydari, AW Hayes… - Human & …, 2021 - journals.sagepub.com
Environmental chemicals and drugs can induce cardiotoxicity, mainly by generating free
radicals. Reactive oxygen species play a critical role in the pathogenesis of cardiac tissue …
radicals. Reactive oxygen species play a critical role in the pathogenesis of cardiac tissue …
Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy
Neuroblastoma is the second most common pediatric malignancy and has a high rate of
spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell …
spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell …
Melatonin attenuates caspase-dependent apoptosis in the thoracic aorta by regulating element balance and oxidative stress in pinealectomised rats
ZB Doğanlar, M Uzun, MA Ovali… - Applied Physiology …, 2019 - cdnsciencepub.com
The aim of this study was to explain the possible mechanisms by which melatonin deficiency
results in cardiovascular injury and to investigate the effects of melatonin administration on …
results in cardiovascular injury and to investigate the effects of melatonin administration on …
Melatonin ameliorates cardiac remodelling in fructose-induced metabolic syndrome rat model by using genes encoding cardiac potassium ion channels
Background Metabolic syndrome comprises a group of disorders, including cardiac
abnormalities. Ventricular arrhythmias observed in metabolic syndrome are due to the …
abnormalities. Ventricular arrhythmias observed in metabolic syndrome are due to the …
Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats
O Doğanlar, ZB Doğanlar, MA Ovali… - Hypertension in …, 2020 - Taylor & Francis
Objective: This study aimed to investigate the effects of melatonin on cardiac oxidative stress
and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were …
and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were …