The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

The hypotensive effects of melatonin are based on a negative correlation between
melatonin levels and blood pressure in humans. However, there is a positive correlation in …

Valproic acid (VPA) is a anticonvulsant and mood-stabilizing agent used to treat epilepsy in
patients of all ages. However, it can cause hepatotoxicity with increased oxidative stress …

Aim: The aim of this study was to investigate the possible mechanisms of ocular damage
induced by pinealectomy (PNX) and preeclampsia (PE), and to determine the cellular and …

Preeclampsia (PE) is known as a major cause of maternal and neonatal morbidity and
mortality. Maternal hypertension, proteinuria, placental dysfunction and imbalance of …

Environmental chemicals and drugs can induce cardiotoxicity, mainly by generating free
radicals. Reactive oxygen species play a critical role in the pathogenesis of cardiac tissue …

Neuroblastoma is the second most common pediatric malignancy and has a high rate of
spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell …

The aim of this study was to explain the possible mechanisms by which melatonin deficiency
results in cardiovascular injury and to investigate the effects of melatonin administration on …

Background Metabolic syndrome comprises a group of disorders, including cardiac
abnormalities. Ventricular arrhythmias observed in metabolic syndrome are due to the …

Objective: This study aimed to investigate the effects of melatonin on cardiac oxidative stress
and apoptosis in the fetal heart in RUPP rats. Methods: The fetal heart samples were …