Improving translation of animal models of addiction and relapse by reverse translation
Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …
animal models, including escalation of drug intake, punished drug seeking and taking …
Treatment of opioid-use disorders
MA Schuckit - New England Journal of Medicine, 2016 - Mass Medical Soc
Treatment of Opioid-Use Disorders | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Opioid withdrawal symptoms, a consequence of chronic opioid use and opioid use disorder: Current understanding and approaches to management
JV Pergolizzi Jr, RB Raffa… - Journal of clinical …, 2020 - Wiley Online Library
What is known and objective Opioid use in the United States has reached unprecedented—
some would even say crisis—levels. Although many individuals use opioid drugs as part of …
some would even say crisis—levels. Although many individuals use opioid drugs as part of …
Animal models of drug relapse and craving after voluntary abstinence: a review
Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …
several decades, this clinical scenario has been studied at the preclinical level using classic …
Stress-induced reinstatement of drug seeking: 20 years of progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
Time to connect: bringing social context into addiction neuroscience
M Heilig, DH Epstein, MA Nader… - Evaluating the Brain …, 2022 - taylorfrancis.com
Research on the neural substrates of drug reward, withdrawal and relapse has yet to be
translated into significant advances in the treatment of addiction. One potential reason is that …
translated into significant advances in the treatment of addiction. One potential reason is that …
Understanding addiction using animal models
Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …
extraordinary global economic impact. Despite decades of research, the options available to …
Circuit and synaptic plasticity mechanisms of drug relapse
High rates of relapse to drug use during abstinence is a defining feature of human drug
addiction. This clinical scenario has been studied at the preclinical level using different …
addiction. This clinical scenario has been studied at the preclinical level using different …
Relapse to opioid seeking in rat models: behavior, pharmacology and circuits
DJ Reiner, I Fredriksson, OM Lofaro… - …, 2019 - nature.com
Lifetime relapse rates remain a major obstacle in addressing the current opioid crisis.
Relapse to opioid use can be modeled in rodent studies where drug self-administration is …
Relapse to opioid use can be modeled in rodent studies where drug self-administration is …
[HTML][HTML] Neurobiology of opioid dependence in creating addiction vulnerability
Opioid drugs are potent modulators of many physiological and psychological processes.
When given acutely, they can elicit the signature responses of euphoria and analgesia that …
When given acutely, they can elicit the signature responses of euphoria and analgesia that …