Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

Adaptive proton therapy

H Paganetti, P Botas, GC Sharp… - Physics in Medicine & …, 2021 - iopscience.iop.org
Radiation therapy treatments are typically planned based on a single image set, assuming
that the patient's anatomy and its position relative to the delivery system remains constant …

Online daily adaptive proton therapy

F Albertini, M Matter, L Nenoff, Y Zhang… - The British journal of …, 2020 - academic.oup.com
It is recognized that the use of a single plan calculated on an image acquired some time
before the treatment is generally insufficient to accurately represent the daily dose to the …

Online adaptive planning methods for intensity-modulated radiotherapy

Z Qiu, S Olberg, D den Hertog, A Ajdari… - Physics in Medicine …, 2023 - iopscience.iop.org
Online adaptive radiation therapy aims at adapting a patient's treatment plan to their current
anatomy to account for inter-fraction variations before daily treatment delivery. As this …

Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy

A Lalonde, B Winey, J Verburg… - Physics in Medicine & …, 2020 - iopscience.iop.org
Adaptive proton therapy (APT) is a promising approach for the treatment of head and neck
cancers. One crucial element of APT is daily volumetric imaging of the patient in the …

Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation

A Lalonde, M Bobić, B Winey, J Verburg… - Radiotherapy and …, 2021 - Elsevier
Background/purpose Setup variations and anatomical changes can severely affect the
quality of head and neck intensity-modulated proton therapy (IMPT) treatments. The impact …

Comparison of the suitability of CBCT-and MR-based synthetic CTs for daily adaptive proton therapy in head and neck patients

A Thummerer, BA De Jong, P Zaffino… - Physics in Medicine …, 2020 - iopscience.iop.org
Cone-beam computed tomography (CBCT)-and magnetic resonance (MR)-images allow a
daily observation of patient anatomy but are not directly suited for accurate proton dose …

Proton therapy for squamous cell carcinoma of the head and neck: early clinical experience and current challenges

S Nuyts, H Bollen, SP Ng, J Corry, A Eisbruch… - Cancers, 2022 - mdpi.com
Simple Summary Proton therapy is a promising type of radiation therapy used to destroy
tumor cells. It has the potential to further improve the outcomes for patients with head and …

GPU‐accelerated Monte Carlo‐based online adaptive proton therapy: a feasibility study

H Feng, SH Patel, WW Wong, JE Younkin… - Medical …, 2022 - Wiley Online Library
Purpose To develop an online graphic processing unit (GPU)‐accelerated Monte Carlo‐
based adaptive radiation therapy (ART) workflow for pencil beam scanning (PBS) proton …

Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy

M Bobić, A Lalonde, GC Sharp… - Physics in Medicine …, 2021 - iopscience.iop.org
The high conformality of intensity-modulated proton therapy (IMPT) dose distributions
causes treatment plans to be sensitive to geometrical changes during the course of a …