DNA-encoded chemical library (DECL) technology is used by the pharmaceutical industry to
discover small molecules capable of modulating biologically relevant targets. DECL …

DNA-encoded chemical libraries (DELs) represent a versatile and powerful technology
platform for the discovery of small-molecule ligands to protein targets of biological and …

Designing new medicines more cheaply and quickly is tightly linked to the quest of exploring
chemical space more widely and efficiently. Chemical space is monumentally large, but …

DNA-encoded chemical libraries (DELs) have emerged as a powerful technology in drug
discovery. The wide adoption of DELs in the pharmaceutical industry and the rapid …

Conspectus DNA-encoded library technology (DELT) is a new screening modality that
allows efficient, cost-effective, and rapid identification of small molecules with potential …

DNA-encoded library (DEL) technology features a time-and cost-effective interrogation
format for the discovery of therapeutic candidates in the pharmaceutical industry. To develop …

Modern-day drug discovery is now blessed with a wide range of high-throughput hit
identification (hit-ID) strategies that have been successfully validated in recent years, with …

The development of DNA-encoded library (DEL) technology introduced new challenges for
the analysis of chemical libraries. It is often useful to consider a chemical library as a stand …

We herein present the first application of the on-DNA Morita-Baylis-Hillman (MBH) reaction
for the creation of pharmaceutically relevant targeted covalent inhibitors (TCIs) with an α …

1-Iodoalkynes and 1, 3-diynes are versatile chemical intermediates and pharmaceutically
valuable ingredients. In this study, copper mediated on-DNA alkyne iodination and Cadiot …