Recurrent implantation failure refers to failure to achieve a clinical pregnancy after transfer of
at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman …

To date 15% of couples are suffering from infertility with 45–50% of males being
responsible. With an increase in paternal age as well as various environmental and lifestyle …

BACKGROUND The best-known role of spermatozoa is to fertilize the oocyte and to transmit
the paternal genome to offspring. These highly specialized cells have a unique structure …

OBJECTIVE: To review the mechanisms responsible for DNA fragmentation in human
sperm, including those occurring during spermatogenesis and transport through the …

Male factor has been considered a major contributory factor to infertility. Along with the
conventional causes for male infertility such as varicocele, cryptorchidism, infections …

Sperm DNA fragmentation (sDF) represents a threat to male fertility, human reproduction
and the health of the offspring. The causes of sDF are still unclear, even if apoptosis …

Sperm plasma membrane lipids are essential for the function and integrity of mammalian
spermatozoa. Various lipid types are involved in each key step within the fertilization …

Almost 50% of the infertility cases are due to male factors. Assisted reproductive
technologies (ARTs) allow to overcome the incapacity of these patients' spermatozoa to …

Apoptosis is an ongoing physiological phenomenon that has been documented to play a
role in male infertility, if deregulated. Caspase activation, externalization of …

Human spermatozoa are characterized by poor functionality and abundant DNA damage
that collude to generate the high incidences of male infertility and miscarriage seen in our …