Orphan nuclear receptor 4A1 (NR4A1) is a transcriptional factor of the nuclear orphan
receptor (NR4A) superfamily that has sparked interest across different research fields in …

Background: Takotsubo syndrome (TTS) is characterized by an acute left ventricular
dysfunction and is associated with life-threating complications in the acute phase. The …

Heart failure is characterized by the constant interplay between the underlying cardiac insult,
degree of myocardial dysfunction and the activity of compensatory neurohormonal …

The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates
cardiac gene expression. Here we show that the levels of an N-terminal proteolytically …

Aim Mutations in the RS-domain of RNA-binding motif protein 20 (RBM20) have recently
been identified to segregate with aggressive forms of familial dilated cardiomyopathy (DCM) …

Diabetic cardiomyopathy is a major complication that significantly contributes to morbidity
and mortality in diabetics with few therapies. Moreover, antidiabetic drugs reported …

Parkin-related mitophagy is vital for endothelial cell viability and the development of
atherosclerosis, although the upstream regulatory factor underlying Parkin-mediated …

Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and
failure. To determine how strain influences the transcriptional response to pressure overload …

Pulmonary arterial hypertension (PAH) is a progressive fatal disease characterised by
abnormal remodelling of pulmonary vessels, leading to increased vascular resistance and …

Numerous studies have been published in the past years investigating the transcriptome of
the zebrafish embryo (ZFE) upon being subjected to chemical stress. Aiming at a more …