Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Chronic pain is a common cause of disability worldwide and remains a global health and
socio‐economic challenge. Current analgesics are either ineffective in a significant …

Evidence supports a strong bidirectional association between depression and Type 2
diabetes mellitus (T2DM). The harmful impact of oxidative stress and chronic inflammation …

Rodent models have been fundamental to understand chronic pain (CP) pathophysiology
and to test for potential treatments. Pain assessment in CP models is most frequently based …

The chronic neuropathic pain-associated psychiatric disorders have seriously disturbed the
quality of patients' life, such as depression and anxiety. Neuroinflammation in the …

Abstract Background and aims Diabetes Mellitus (DM) and depression occur comorbidly
and share some pathophysiological mechanisms. The course of depression in patients with …

Naringenin (NAR) has various biological activities but low bioavailability. The current study
examines the effect of Naringenin-loaded hybridized nanoparticles (NAR-HNPs) and NAR …

Introduction Pain is a multidimensional experience involving the biological, psychological,
and social dimensions of each individual. Particularly, the biological aspects of pain …

The novel targets considered in the recent research related to the treatment of depression
include connexins, peroxisome proliferator activated receptor (PPAR), ω-3 fatty acids …

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders in the
United States, with one in five adults experiencing the disorder in their lifetimes. Yet more …