Immunomodulation in the treatment of periodontitis: Progress and perspectives

B Yang, X Pang, Z Li, Z Chen, Y Wang - Frontiers in immunology, 2021 - frontiersin.org
Periodontitis is one of the most common dental diseases. Compared with healthy
periodontal tissues, the immune microenvironment plays the key role in periodontitis by …

Maintaining homeostatic control of periodontal bone tissue

JD Hathaway‐Schrader, CM Novince - Periodontology 2000, 2021 - Wiley Online Library
Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Application of ligature-induced periodontitis in mice to explore the molecular mechanism of periodontal disease

P Lin, H Niimi, Y Ohsugi, Y Tsuchiya… - International journal of …, 2021 - mdpi.com
Periodontitis is an inflammatory disease characterized by the destruction of the
periodontium. In the last decade, a new murine model of periodontitis has been widely used …

Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets

N Neurath, M Kesting - Frontiers in Immunology, 2024 - frontiersin.org
Chronic inflammatory processes in the oral mucosa and periodontitis are common disorders
caused by microflora and microbial biofilms. These factors activate both the innate and …

[HTML][HTML] Macrophages in periodontitis: a dynamic shift between tissue destruction and repair

L Yin, X Li, J Hou - Japanese Dental Science Review, 2022 - Elsevier
Periodontitis is a chronic inflammatory disease associated with a dysbiotic bacterial biofilm
in the subgingival environment that may disturb the balance between the oral microbiome …

The Th17/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis

J Deng, C Lu, Q Zhao, K Chen, S Ma… - Journal of periodontal …, 2022 - Wiley Online Library
Periodontopathic bacteria constantly stimulate the host, which causes an immune response,
leading to host‐induced periodontal tissue damage. The complex interaction and imbalance …

[HTML][HTML] Salivary IL-1β, IL-6, and IL-10 Are Key Biomarkers of Periodontitis Severity

M Relvas, A Mendes-Frias, M Gonçalves… - International Journal of …, 2024 - mdpi.com
To explore severity and progression biomarkers, we examined the clinical relevance of
multiple cytokines and mediators involved in the inflammatory response in periodontitis. A …

Omega-3 polyunsaturated fatty acids EPA and DHA as an adjunct to non-surgical treatment of periodontitis: a randomized clinical trial

M Stańdo, P Piatek, M Namiecinska, P Lewkowicz… - Nutrients, 2020 - mdpi.com
Periodontitis is a chronic multifactorial inflammatory disease that leads to the loss of
supportive tissues around the teeth with gradual deterioration of masticatory function and …

Association between periodontitis and inflammatory comorbidities: The common role of innate immune cells, underlying mechanisms and therapeutic targets

Q Wu, W Zhang, Y Lu, H Li, Y Yang, F Geng… - International …, 2024 - Elsevier
Periodontitis, which is related to various systemic diseases, is a chronic inflammatory
disease caused by periodontal dysbiosis of the microbiota. Multiple factors can influence the …

Exosomes derived from human gingival mesenchymal stem cells attenuate the inflammatory response in periodontal ligament stem cells

J Sun, Z Wang, P Liu, Y Hu, T Li, J Yang, P Gao… - Frontiers in …, 2022 - frontiersin.org
This study aimed to explore the effects of exosomes derived from human gingival
mesenchymal stem cells (GMSC-Exo) on the inflammatory response of periodontal ligament …