The bovine tuberculoid granuloma is the hallmark lesion of bovine tuberculosis (bTB) due to
Mycobacterium bovis infection. The pathogenesis of bTB, and thereby the process of bovine …

Mycobacterium bovis has the largest host range of the Mycobacterium tuberculosis complex
and infects domestic animal species, wildlife, and humans. The presence of global wildlife …

Hoof diseases are a major welfare and economic issue in the global dairy cattle production
industry, which can be minimized through improved management and breeding practices …

Whole blood based assays, particularly interferon gamma (IFN-γ) release assays (IGRAs),
are used for the diagnosis of both bovine and human tuberculosis (TB). The aim of the …

Type 3 immunity encompasses innate and adaptive immune responses mediated by cells
that produce the signature cytokines IL-17A and IL-17F. This class of effector immunity is …

Despite the threat posed by tuberculosis (TB) to the protected European bison (Bison
bonasus), no validated TB tests exist for this species. This pilot study evaluates two tests …

Gene transcription studies have identified dual roles for the cytokines IL-17A and IL-22 in
bovine tuberculosis, where they show potential as both predictors of vaccine success and …

Central memory T cell (Tcm) and polyfunctional CD4 T cell responses contribute to vaccine-
elicited protection with both human and bovine tuberculosis (TB); however, their combined …

Immunological memory is a central feature of adaptive immunity. Memory B cells are
generated upon stimulation with antigen presented by follicular dendritic cells in the …

Background and objectives Animal tuberculosis (TB) is a multi-host disease involving a wide
variety of domestic and wild mammals and causing a significant economic burden and …