Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number
of PCa patients continues to rise despite the availability of effective treatments in recent …

Several signaling pathways and basic metabolites are responsible for the control of
metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism …

Simple Summary Cancer is a multifactorial disease characterized by excessive cell
proliferation in a specific organ. The most common treatments include chemotherapy …

Cancer cells underlie the dysregulated metabolism of carbohydrate, lipid and protein and
thereby, employ interconnected cross-linked signaling pathways to supply adequate energy …

Previously, our laboratory demonstrated that a deregulated E2F5/p38/SMAD3 axis was
associated with uncontrolled cellular proliferation in prostate cancer (PCa). Here, we …

Objective: The purpose of this study was to evaluate the anticancer effects of Ophiopogonin
D′(OPD′, a natural product extracted from a traditional Chinese medicine (Radix …

Intracellular cyclic AMP and/or cyclic GMP are characterized in the 1960th. These second
messengers, hydrolysed specifically by cyclic nucleotide phosphodiesterase (PDE), play a …

Prostate cancer is the second most commonly diagnosed cancer in men worldwide, which is
almost incurable, once it progresses into the metastatic stage. Adriamycin (ADR) is a known …

Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. A
geographic variation on the burden of the disease suggested that the environment, genetic …

Background Prostate carcinoma is the second most common cancer among men worldwide.
Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) …