The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis
formation can be considered as a culmination of the Darwinian evolutionary process within …

Worldwide, colorectal cancer (CRC) is the third most common cancer, with the highest
mortality rates occurring in Central Europe. The use of chemotherapy to treat CRC is limited …

The release of circulating tumor cells (CTCs) into vasculature is an early event in the
metastatic process. The analysis of CTCs in patients has recently received widespread …

Increasing evidence suggests that circulating tumour cells (CTCs) are responsible for
metastatic relapse and this has fuelled interest in their detection and quantification. Although …

Current models suggest that at a certain but yet undefined time point of tumour development
malignant cells with an aggressive phenotype start to disseminate via the blood stream into …

Colorectal cancer (CRC) is one of the most commonly diagnosed and lethal cancers
worldwide. It is a multistep process that requires the accumulation of genetic/epigenetic …

The epithelial-mesenchymal transition (EMT) is a highly conserved cellular process that
transforms epithelial cells into mesenchymal cells; EMT is involved in normal …

Colorectal cancer is one of the most common malignant tumors worldwide. A model of
cancer development involving cancer stem cells has been put forward because it provides a …