Pharmaceutical production remains one of the last industries that predominantly uses batch
processes, which are inefficient and can cause drug shortages due to the long lead times or …

The rejection of process impurities from crystallizing products is an essential step for the
purification of pharmaceutical drugs and for the isolation of active pharmaceutical …

Despite their widespread use for purification, our current methods for the development of
solution crystallization processes lack a sufficient understanding on how impurities …

To facilitate integrated end-to-end pharmaceutical manufacturing using digital design, a
model capable of transferring material property information between operations to predict …

In this work dynamic models of the continuous crystallization, filtration, deliquoring, washing,
and drying steps are introduced, which are developed in the open-source pharmaceutical …

In this paper, we describe the development of a digital twin for a Michael addition continuous-
flow process using data generated from dynamic flow experimentation. We commenced our …

Continuous crystallization plays a pivotal role in the transition to continuous manufacturing
that the pharmaceutical industry is currently undertaking. Alas, the development of a …

A digital-first approach to produce quality particles of an active pharmaceutical ingredient
across crystallisation, washing and drying is presented, minimising material requirements …

Traditional pharmaceutical manufacturing operates around a supply chain that is subject to
complex logistics and is vulnerable to spikes in demand and interruptions. In this context …

The development of a photochemical bromination/alkylation sequence as part of a
continuous process for the synthesis of an intermediate en route to AMG 423 is discussed …