Unraveling molecular aberrations and pioneering therapeutic strategies in osteosarcoma
P Yan, J Wang, B Yue, X Wang - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Osteosarcoma, a rare primary bone cancer, presents diverse molecular aberrations that
underscore its complexity. Despite the persistent endeavors by researchers, the limited …
underscore its complexity. Despite the persistent endeavors by researchers, the limited …
Drugging hijacked kinase pathways in pediatric oncology: Opportunities and current scenario
MF Candido, M Medeiros, LC Veronez, D Bastos… - Pharmaceutics, 2023 - mdpi.com
Childhood cancer is considered rare, corresponding to~ 3% of all malignant neoplasms in
the human population. The World Health Organization (WHO) reports a universal …
the human population. The World Health Organization (WHO) reports a universal …
Integrative multi-OMICs identifies therapeutic response biomarkers and confirms fidelity of clinically annotated, serially passaged patient-derived xenografts …
PH Pandya, AJ Jannu, K Bijangi-Vishehsaraei… - Cancers, 2022 - mdpi.com
Simple Summary Solid tumors account for~ 60% of pediatric, as well as adolescent and
young adult (AYA), cancers, and outcomes for patients with these progressive diseases …
young adult (AYA), cancers, and outcomes for patients with these progressive diseases …
Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial
GLS Sholler, G Bergendahl, EC Lewis, J Kraveka… - Genome Medicine, 2024 - Springer
Background Children with relapsed central nervous system (CNS tumors), neuroblastoma,
sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial …
sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial …
Comparing the therapeutic potential of T cell receptors from tumors and healthy donors for adoptive T cell therapy in cancer
L Rosenberger - 2024 - refubium.fu-berlin.de
The infiltration of T cells into the tumor tissue is in many cases insufficient to prevent tumor
progression. In addition, tumor-infiltrating lymphocytes (TILs) in the tumor are chronically …
progression. In addition, tumor-infiltrating lymphocytes (TILs) in the tumor are chronically …
Targeting Replication Stress in Pediatric and AYA Osteosarcoma
K Pollok - 2023 - apps.dtic.mil
Osteosarcoma (OS) is extremely challenging to treat for 25-50% of the patients already have
metastatic disease at the time of diagnosis. The purpose of this proposal is to improve …
metastatic disease at the time of diagnosis. The purpose of this proposal is to improve …
Therapeutic Targeting of the Cell Cycle in Pediatric, Adolescent and Young Adult Osteosarcoma
F Barghi - 2024 - scholarworks.iupui.edu
Treating pediatric, adolescent, and young adult (AYA) osteosarcoma (OS) is challenging
due to its aggressiveness, genetic complexity, lack of standard therapies, and chemotherapy …
due to its aggressiveness, genetic complexity, lack of standard therapies, and chemotherapy …