Systems serology detects functionally distinct coronavirus antibody features in children and elderly

KJ Selva, CE Van De Sandt, MM Lemke, CY Lee… - Nature …, 2021 - nature.com
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared
to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses …

Comparison of seroconversion in children and adults with mild COVID-19

ZQ Toh, J Anderson, N Mazarakis, M Neeland… - JAMA network …, 2022 - jamanetwork.com
Importance The immune response in children with SARS-CoV-2 infection is not well
understood. Objective To compare seroconversion in nonhospitalized children and adults …

IgG3 and IgM identified as key to SARS-CoV-2 neutralization in convalescent plasma pools

C Kober, S Manni, S Wolff, T Barnes, S Mukherjee… - PLoS …, 2022 - journals.plos.org
Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most
important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed …

Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucumán, Argentina

RE Chahla, RH Tomas-Grau, SI Cazorla… - The Lancet Regional …, 2022 - thelancet.com
Summary Background Gam-COVID-Vac (SPUTNIK V) has been granted emergency use
authorization in 70 nations and has been administered to millions worldwide. However …

SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

W Zhang, BY Chua, KJ Selva, L Kedzierski… - Nature …, 2022 - nature.com
Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …

Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities

W Zhang, L Kedzierski, BY Chua, M Mayo, C Lonzi… - Nature …, 2023 - nature.com
High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we
found that Australian First Nations peoples elicit effective immune responses to COVID-19 …

Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells

THO Nguyen, LC Rowntree, LF Allen, BY Chua… - Cell Reports …, 2023 - cell.com
Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond
poorly to vaccination. Relative deficits in immunity are, however, unclear, especially after 3 …

Persistence of MERS-CoV-spike-specific B cells and antibodies after late third immunization with the MVA-MERS-S vaccine

LM Weskamm, A Fathi, MP Raadsen, AZ Mykytyn… - Cell Reports …, 2022 - cell.com
Summary The Middle East respiratory syndrome (MERS) is a respiratory disease caused by
MERS coronavirus (MERS-CoV). In follow up to a phase 1 trial, we perform a longitudinal …

[HTML][HTML] Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations

JR Habel, BY Chua, L Kedzierski, KJ Selva… - JCI insight, 2023 - ncbi.nlm.nih.gov
Pregnancy poses a greater risk for severe COVID-19; however, underlying immunological
changes associated with SARS-CoV-2 during pregnancy are poorly understood. We defined …

Correlation between in vitro neutralization assay and serological tests for protective antibodies detection

MA Bonifacio, R Laterza, A Vinella, A Schirinzi… - International Journal of …, 2022 - mdpi.com
Serological assays are useful in investigating the development of humoral immunity against
SARS-CoV-2 in the context of epidemiological studies focusing on the spread of protective …