Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Bone has a remarkable endogenous regenerative capacity that enables scarless healing
and restoration of its prior mechanical function, even under challenging conditions such as …

In the mammalian skeletal system, osteogenesis and angiogenesis are intimately linked
during bone growth and regeneration in bone modeling and during bone homeostasis in …

The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of
extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair …

Abstract 3D printed scaffolds hold promising perspective for bone tissue regeneration.
Inspired by process of bone development stage, 3D printed scaffolds with rapid internal …

The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …

We review the characteristics of osteoblast differentiation and bone matrix synthesis. Bone in
air breathing vertebrates is a specialized tissue that developmentally replaces simpler solid …

Vascular endothelial growth factor-A (VEGF) is one of the most important growth factors for
regulation of vascular development and angiogenesis. Since bone is a highly vascularized …

Bone regeneration is a complex process requiring highly orchestrated interactions between
different cells and signals to form new mineralized tissue. Blood vessels serve as a structural …