Botulinum toxin: chemistry, pharmacology, toxicity, and immunology

MF Brin - Muscle & Nerve: Official Journal of the American …, 1997 - Wiley Online Library
The seven serotypes of botulinum toxin (BTX) produced by Clostridium botulinum exert their
paralytic effect by inhabiting acetylcholine release at the neuromuscular junction. Each of …

Immunogenicity of botulinum toxins

M Naumann, LM Boo, AH Ackerman… - Journal of neural …, 2013 - Springer
Botulinum neurotoxins are formulated biologic pharmaceuticals used therapeutically to treat
a wide variety of chronic conditions, with varying governmental approvals by country. Some …

Botulinum toxin A for axillary hyperhidrosis (excessive sweating)

M Heckmann, AO Ceballos-Baumann… - New England Journal …, 2001 - Mass Medical Soc
Background Treatment of primary focal hyperhidrosis is often unsatisfactory. Botulinum toxin
A can stop excessive sweating by blocking the release of acetylcholine, which mediates …

Response and immunoresistance to botulinum toxin injections

J Jankovic, K Schwartz - Neurology, 1995 - AAN Enterprises
Botulinum toxin antibodies (ABS) may be a reason why occasionally patients do not have a
response to injections with botulinum toxin type A (BTX). We tested 86 patients with cervical …

Botulinum-A toxin as a treatment of detruosor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients

B Schurch, D Hauri, B Rodic, A Curt, M Meyer… - The Journal of …, 1996 - auajournals.org
Purpose: The paralytic effect of botulinum-A toxin injections on the external urethral
sphincter was investigated prospectively in patients with neurogenic voiding disorders …

Botulinum toxin therapy, immunologic resistance, and problems with available materials

G Borodic, E Johnson, M Goodnough, E Schantz - Neurology, 1996 - AAN Enterprises
Botulinum toxin injections have become an extremely useful therapeutic modality in the
treatment of certain segmental movement disorders such as blepharospasm, adult onset …

Positive effects of extracorporeal shock wave therapy on spasticity in poststroke patients: a meta-analysis

P Guo, F Gao, T Zhao, W Sun, B Wang, Z Li - Journal of Stroke and …, 2017 - Elsevier
Background Spasticity is a common and serious complication following a stroke, and many
clinical research have been conducted to evaluate the effect of extracorporeal shock wave …

Botulinum toxin A treatment in facial palsy synkinesis: a systematic review and meta-analysis

FW de Jongh, AWMA Schaeffers, ZE Kooreman… - European archives of …, 2023 - Springer
Background Synkinesis is defined as involuntary movements accompanying by voluntary
movements and can occur during the aftermath of peripheral facial palsy, causing functional …

The beneficial antispasticity effect of botulinum toxin type A is maintained after repeated treatment cycles

AMO Bakheit, NV Fedorova, AA Skoromets… - Journal of Neurology …, 2004 - jnnp.bmj.com
Objective: To study the efficacy, safety, and incidence of BtxA antibody formation with
repeated treatments with BtxA in post-stroke upper limb muscle spasticity. Methods: The …

Pharmacologic characterization of botulinum toxin for basic science and medicine

LB Pearce, ER First, RD Maccallum, A Gupta - Toxicon, 1997 - Elsevier
The use of Botulinum neurotoxin (BoNT) is increasing in both clinical and basic science.
Clinically, intramuscular injection of nanogram quantities of BoNT is fast becoming the …