Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

The sense of taste, or gustation, is mediated by taste buds, which are housed in specialized
taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud …

Mesodermal signaling is critical for patterning the embryonic endoderm into different tissue
domains. Classical tissue transplant experiments in the chick and recent studies in the …

Primate molar shapes reflect developmental and ecological processes. Development may
constrain as well as facilitate evolution of new tooth shapes, affecting how reliable dental …

Integuments form the boundary between an organism and the environment. The evolution of
novel developmental mechanisms in integuments and appendages allows animals to live in …

This study addresses the role of sonic hedgehog (shh) in increasing oral–pharyngeal
constructive traits (jaws and taste buds) at the expense of eyes in the blind cavefish …

To examine the role of development in the origin of evolutionary novelties, we investigated
the developmental mechanisms involved in the formation of a complex morphological …

Wnt and Shh signaling pathways are critical for the development and maturation of many
epithelial tissues. Both pathways have roles in stem cell maintenance, tissue development …

Taste is one of the fundamental senses, and it is essential for our ability to ingest nutritious
substances and to detect and avoid potentially toxic ones. Taste buds, which are clusters of …

Taste buds on the anterior part of the tongue develop in conjunction with epithelial–
mesenchymal specializations in the form of gustatory (taste) papillae. Sonic hedgehog (Shh) …