Myeloid derived suppressor cells interactions with natural killer cells and pro-angiogenic activities: roles in tumor progression
Myeloid-derived suppressor cells (MDSCs) contribute to the induction of an immune
suppressive/anergic, tumor permissive environment. MDSCs act as immunosuppression …
suppressive/anergic, tumor permissive environment. MDSCs act as immunosuppression …
Natural killer cells as key players of tumor progression and angiogenesis: old and novel tools to divert their pro-tumor activities into potent anti-tumor effects
Immune cells, as a consequence of their plasticity, can acquire altered phenotype/functions
within the tumor microenvironment (TME). Some of these aberrant functions include …
within the tumor microenvironment (TME). Some of these aberrant functions include …
Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion
Malignant pleural effusion (MPE) is indicative of terminal malignancy with a uniformly fatal
prognosis. Often, two distinct compartments of tumour microenvironment, the effusion and …
prognosis. Often, two distinct compartments of tumour microenvironment, the effusion and …
The ovarian cancer tumor immune microenvironment (TIME) as target for therapy: a focus on innate immunity cells as therapeutic effectors
Ovarian cancer (OvCA) accounts for one of the leading causes of death from gynecologic
malignancy. Despite progress in therapy improvements in OvCA, most patients develop a …
malignancy. Despite progress in therapy improvements in OvCA, most patients develop a …
NK cells-directed therapies target circulating tumor cells and metastasis
Metastasis is the major cause of cancer-related deaths. Invasive primary cancers often
metastasize after circulating tumor cells (CTCs) enter the bloodstream or lymph node to …
metastasize after circulating tumor cells (CTCs) enter the bloodstream or lymph node to …
Natural killer cell interactions with myeloid derived suppressor cells in the tumor microenvironment and implications for cancer immunotherapy
The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …
Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma
H Sun, L Liu, Q Huang, H Liu, M Huang, J Wang… - Cancer immunology …, 2019 - AACR
The discovery of CD49a+ liver-resident natural killer (NK) cells in mice alters our view of NK
cells and provides another opportunity to study NK cells. Although evidence has suggested …
cells and provides another opportunity to study NK cells. Although evidence has suggested …
Prostate cancer peripheral blood NK cells show enhanced CD9, CD49a, CXCR4, CXCL8, MMP-9 production and secrete monocyte-recruiting and polarizing factors
Natural killer (NK) cells, effector lymphocytes of the innate immunity, have been shown to be
altered in several cancers, both at tissue and peripheral levels. We have shown that in Non …
altered in several cancers, both at tissue and peripheral levels. We have shown that in Non …
The immune microenvironment in mesothelioma: mechanisms of resistance to immunotherapy
GJ Chu, N Van Zandwijk, JEJ Rasko - Frontiers in Oncology, 2019 - frontiersin.org
Although mesothelioma is the consequence of a protracted immune response to asbestos
fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches …
fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches …
Exploring the clinical value of tumor microenvironment in platinum-resistant ovarian cancer
Platinum resistance in epithelial ovarian cancer (OvCa) is rising at an alarming rate, with
recurrence of chemo-resistant high grade serous OvCa (HGSC) in roughly 75% of all …
recurrence of chemo-resistant high grade serous OvCa (HGSC) in roughly 75% of all …