Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis, in vitro biological evaluation, and in silico ADMET analysis with …
Recently, scientists developed a powerful strategy called “one drug-multiple targets” to
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
discover vital and unique therapies to fight the most challenging diseases. Novel derivatives …
In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities …
AS Hassan, NM Morsy… - Drug Development …, 2023 - Wiley Online Library
The strategy of utilizing nitrogen compounds in various biological applications has recently
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
emerged as a powerful approach to exploring novel classes of therapeutics to face the …
Development of novel pyrazole, imidazo [1, 2-b] pyrazole, and pyrazolo [1, 5-a] pyrimidine derivatives as a new class of COX-2 inhibitors with immunomodulatory …
Searching for new compounds with anti-inflammatory properties is a significant target since
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …
inflammation is a major cause of pain. A series of pyrazole, imidazopyrazolone, and …
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm …
AY Alzahrani, YA Ammar, M Abu-Elghait, MA Salem… - Bioorganic …, 2022 - Elsevier
Nowadays, it's imperative to develop novel antimicrobial agents active against both drug-
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
sensitive and drug-resistant bacterial infections with favorable profiles as high efficacy, low …
Developing a new multi-featured chitosan-quinoline Schiff base with potent antibacterial, antioxidant, and antidiabetic activities: Design and molecular modeling …
YM Abdel-Baky, AM Omer, EM El-Fakharany… - Scientific reports, 2023 - nature.com
A new chitosan Schiff base was developed via the reaction of chitosan (CH) with 2-chloro-3-
formyl-7-ethoxy quinoline (Q) derivative. The alteration in the chemical structure and …
formyl-7-ethoxy quinoline (Q) derivative. The alteration in the chemical structure and …
Synthesis, characterization, thermal properties, antimicrobial evaluation, ADMET study, and molecular docking simulation of new mono Cu (II) and Zn (II) complexes …
One of the interesting research fields is developing and assessing novel metal-containing
medications. A new isatin-3-thiosemicarbazone derivative 4 was synthesized by two …
medications. A new isatin-3-thiosemicarbazone derivative 4 was synthesized by two …
Synthesis, characterization, and in vitro antibacterial activity of some new pyridinone and pyrazole derivatives with some in silico ADME and molecular modeling study
KE Saadon, NMH Taha, NA Mahmoud… - Journal of the Iranian …, 2022 - Springer
A new series of pyridine-2-one and pyrazole derivatives were designed and synthesized
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
based on cyanoacrylamide derivatives containing 2, 4-dichlro aniline and 6-methyl 2-amino …
A novel of quinoxaline derivatives tagged with pyrrolidinyl scaffold as a new class of antimicrobial agents: Design, synthesis, antimicrobial activity, and molecular …
MM Abdelgalil, YA Ammar, GAME Ali, AK Ali… - Journal of Molecular …, 2023 - Elsevier
Globally, infectious diseases are becoming harder to treat due to antibiotic resistance, which
has reached high levels. Additionally, developing new therapeutic options to combat the …
has reached high levels. Additionally, developing new therapeutic options to combat the …
Evaluation of the anti-proliferative activity of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives as a new class of EGFR Wt and VEGFR-2 inhibitors with apoptotic …
RR Raslan, YA Ammar, SA Fouad, SA Hessein… - RSC …, 2023 - pubs.rsc.org
Developing new agents for cancer treatment remains a top priority because it is one of the
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
deadliest worldwide. A new series of 2-oxo-pyridine and 1′ H-spiro-pyridine derivatives …
Development of new spiro [1, 3] dithiine-4, 11′-indeno [1, 2-b] quinoxaline derivatives as S. aureus Sortase A inhibitors and radiosterilization with molecular …
Multi-drug resistant microbes have become a severe threat to human health and arise a
worldwide concern. A total of fifteen spiro-1, 3-dithiinoindenoquinoxaline derivatives 2–7 …
worldwide concern. A total of fifteen spiro-1, 3-dithiinoindenoquinoxaline derivatives 2–7 …