Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …

Triterpenoids are natural products from plants and many other organisms that have various
biological activities, such as antitumor, antiviral, antimicrobial, and protective activities. This …

Betulinic acid (BA) and its natural analogues betulin (BN), betulonic (BoA), and 23-
hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in …

Pentacyclic triterpenoids are well-known phytochemicals with various biological activities
commonly found in plants as secondary metabolites. The wide range of biological activities …

Naturally occurring pentacyclic lupane triterpenoids such as betulin (1) or betulinic acid (2)
and their synthetic derivatives display a broad spectrum of biological activities and …

Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

Breast cancer is one of the most prevalent malignant diseases, and one of the main causes
of mortality among women across the world. Despite advances in chemotherapy, drug …

Natural products are one of the important sources for the discovery of new drugs. Betulinic
acid (BA), a pentacyclic triterpenoid widely distributed in the plant kingdom, exhibits …

Click reactions between alkynes and azides using the privileged scaffold of triterpenes have
been of interest for biological chemistry. Many publications deal with the synthesis of novel …

Pentacyclic triterpenes, such as betulinic, ursolic, and oleanolic acids are efficient and
selective anticancer agents whose underlying mechanisms of action have been widely …