Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with
immune cells and strategic localization between the dark and light zones to clonally expand …

T follicular helper (TFH) cells are essential for effective antibody responses, but deciphering
the intrinsic wiring of mouse TFH cells has long been hampered by the lack of a reliable …

Highlights•Tfh cells are phenotypically diverse.•Complex signaling and metabolic networks
control Tfh cell differentiation.•The context in which Tfh are generated affects their …

Staphylococcus aureus remains a leading global cause of bacterial infection-associated
mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an …

CXCR5 is a hallmark of T follicular helper (Tfh) cells. The mechanism of CXCR5 induction,
however, is still incompletely understood. In this study, we report that in mice with the …

Pro-inflammatory immune responses are rapidly suppressed during blood-stage malaria but
the molecular mechanisms driving this regulation are still incompletely understood. In this …

TIGIT, a co-inhibitory receptor found on T cells and NK cells, transmits inhibitory signals
upon binding to its ligand. This interaction suppresses the activation of various signaling …

Introduction The role of the host immune response could be critical in the development of
Treponema pallidum (Tp) infection in individuals with latent syphilis. This study aims to …

非小细胞肺癌(non-small cell lung cancer, NSCLC) 作为全球范围内频发且极具侵袭性的癌症
之一, 传统的手术治疗, 放化疗及靶向治疗等方法往往由于其固有的局限性 …

Non-small cell lung cancer (NSCLC) is a prevalent and aggressive global malignancy.
Conventional surgical treatments, radiotherapy, chemotherapy, and targeted therapies often …