Protective role and functional engineering of neuropeptides in depression and anxiety: an overview

N Okdeh, G Mahfouz, J Harb, JM Sabatier, R Roufayel… - Bioengineering, 2023 - mdpi.com
Behavioral disorders, such as anxiety and depression, are prevalent globally and touch
children and adults on a regular basis. Therefore, it is critical to comprehend how these …

Histamine and histamine receptors: Roles in major depressive disorder

H Qian, C Shu, L Xiao, G Wang - Frontiers in Psychiatry, 2022 - frontiersin.org
Although the incidence of major depressive disorder (MDD) is high and its social impact is
great, we still know very little about the pathophysiology of depression. The monoamine …

Melanin-concentrating hormone (MCH): role in REM sleep and depression

P Torterolo, C Scorza, P Lagos… - Frontiers in …, 2015 - frontiersin.org
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by
neurons of the lateral sector of the posterior hypothalamus and zona incerta. MCHergic …

Chronic sleep disruption induces depression-like behavior in adolescent male and female mice and sensitization of the hypothalamic-pituitary-adrenal axis in …

M Murack, R Chandrasegaram, KB Smith… - Behavioural brain …, 2021 - Elsevier
Depression is a prevalent mood disorder responsible for reduced quality of life for over 264
million people. Depression commonly develops during adolescence and becomes twice as …

Sleep-wake neurobiology

G Vanini, P Torterolo - … and Sleep: Molecular, Functional and Clinical …, 2021 - Springer
Sleep and wakefulness are complex, tightly regulated behaviors that occur in virtually all
animals. With recent exciting developments in neuroscience methodologies such as …

Melanin-concentrating hormone: a new sleep factor?

P Torterolo, P Lagos, JM Monti - Frontiers in neurology, 2011 - frontiersin.org
Neurons containing the neuropeptide melanin-concentrating hormone (MCH) are mainly
located in the lateral hypothalamus and the incerto-hypothalamic area, and have …

The melanin-concentrating hormone system as a target for the treatment of sleep disorders

LE Potter, CR Burgess - Frontiers in neuroscience, 2022 - frontiersin.org
Given the widespread prevalence of sleep disorders and their impacts on health, it is critical
that researchers continue to identify and evaluate novel avenues of treatment. Recently the …

Ciliary melanin‐concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex‐independent manner

GB Diniz, DS Battagello, MO Klein… - Journal of …, 2020 - Wiley Online Library
Melanin‐concentrating hormone (MCH) is a ubiquitous vertebrate neuropeptide
predominantly synthesized by neurons of the diencephalon that can act through two G …

Nucleus accumbens melanin-concentrating hormone signaling promotes feeding in a sex-specific manner

SJ Terrill, KS Subramanian, R Lan, CM Liu… - …, 2020 - Elsevier
Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced in the
lateral hypothalamus and zona incerta that increases food intake. The neuronal pathways …

Microinjection of melanin concentrating hormone into the lateral preoptic area promotes non-REM sleep in the rat

L Benedetto, Z Rodriguez-Servetti, P Lagos… - Peptides, 2013 - Elsevier
The ventrolateral preoptic area (VLPO) has been recognized as one of the key structures
responsible for the generation of non-REM (NREM) sleep. The melanin-concentrating …