Pseudomonas aeruginosa is one of the six bacterial pathogens, Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various
important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di …

The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that
regulates many bacterial behaviors and is of key importance for driving the lifestyle switch …

Biofilms have conventionally been perceived as dense bacterial masses on surfaces,
following the five-step model of development. Initial biofilm research focused on surface …

Twenty-five years have passed since the discovery of cyclic dimeric (3′→ 5′) GMP (cyclic
di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial …

Pseudomonas aeruginosa is a key pathogen of chronic infections in the lungs of cystic
fibrosis patients and in patients suffering from chronic wounds of diverse etiology. In these …

Gram-negative bacterial pathogens have an outer membrane that restricts entry of
molecules into the cell. Water-filled protein channels in the outer membrane, so-called …

Pseudomonas aeruginosa biofilms and the capacity of the bacterium to coexist and interact
with a broad range of microorganisms have a substantial clinical impact. This review focuses …

Cell-to-cell communication is a major process that allows bacteria to sense and coordinately
react to the fluctuating conditions of the surrounding environment. In several pathogens, this …

Biofilms are communities of microorganisms embedded in extracellular polymeric
substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free …